World's first rigid endoscope system for hyperspectral imaging during medical procedures

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Hyperspectral imaging (HSI) is simply a state-of-the-art method that captures and processes accusation crossed a fixed electromagnetic spectrum. Unlike accepted imaging techniques that seizure ray strength astatine circumstantial wavelengths, HSI collects a afloat spectrum astatine each pixel successful an image. This rich | spectral information enables nan favoritism betwixt different materials and substances based connected their unsocial spectral signatures. Near-infrared hyperspectral imaging (NIR-HSI) has attracted important attraction successful nan nutrient and business fields arsenic a non-destructive method for analyzing nan creation of objects. A notable facet of NIR-HSI is over-thousand-nanometer (OTN) spectroscopy, which tin beryllium utilized for nan recognition of integrated substances, their attraction estimation, and 2D representation creation. Additionally, NIR-HSI tin beryllium utilized to get accusation heavy into nan body, making it useful for nan visualization of lesions hidden successful normal tissues.

Various types of HSI devices person been developed to suit different imaging targets and situations, specified arsenic for imaging nether a microscope aliases portable imaging and imaging successful confined spaces. However, for OTN wavelengths, mean visible cameras suffer sensitivity and only a fewer commercially disposable lenses beryllium that tin correct chromatic aberration. Moreover, it is basal to conception cameras, optical systems, and illumination systems for portable NRI-HSI devices, but nary instrumentality that tin get NIR-HSI pinch a rigid scope, important for portability, has been reported yet.

Now, successful a caller study, a squad of researchers, led by Professor Hiroshi Takemura from Tokyo University of Science (TUS) and including Toshihiro Takamatsu, Ryodai Fukushima, Kounosuke Sato, Masakazu Umezawa, and Kohei Soga, each from TUS, Hideo Yokota from RIKEN, and Abian Hernandez Guedes and Gustavo M. Calico, some from nan University of Las Palmas de Gran Canaria, has precocious developed nan world's first rigid endoscope strategy tin of HSI from visible to OTN wavelengths. Their findings were published successful Volume 32, Issue 9 of Optics Express connected April 17, 2024.

At nan halfway of this innovative strategy lies a supercontinuum (SC) ray root and an acoustic-opto tunable select (AOTF) that tin emit circumstantial wavelengths. Prof. Takemura explains, "An SC ray root tin output aggravated coherent achromatic light, whereas an AOTF tin extract ray containing a circumstantial wavelength. This operation offers easy ray transmission to nan ray guideline and nan expertise to electrically move betwixt a wide scope of wavelengths wrong a millisecond."

The squad verified nan optical capacity and classification expertise of nan system, demonstrating its capacity to execute HSI successful nan scope of 490–1600 nm, enabling visible arsenic good arsenic NIR-HSI. Additionally, nan results highlighted respective advantages, specified arsenic nan debased ray powerfulness of extracted wavelengths, enabling non-destructive imaging, and downsizing capability. Moreover, a much continuous NIR spectrum tin beryllium obtained compared to that of accepted rigid-scope-type devices.

To show their system's capability, nan researchers utilized it to get nan spectra of six types of resins and employed a neural web to categorize nan spectra pixel-by-pixel successful aggregate wavelengths. The results revealed that erstwhile nan OTN wavelength scope was extracted from nan HSI information for training, nan neural web could categorize 7 different targets, including nan six resins and a achromatic reference, pinch an accuracy of 99.6%, reproducibility of 93.7%, and specificity of 99.1%. This intends that nan strategy tin successfully extract molecular vibration accusation of each resin astatine each pixel.

Prof. Takemura and his squad besides identified respective early investigation directions for improving this method, including enhancing image value and callback successful nan visible region and refining nan creation of nan rigid endoscope to correct chromatic aberrations complete a wide area. With these further advancements, successful nan coming years, nan projected HSI exertion is expected to facilitate caller applications successful business inspection and value control, moving arsenic a "superhuman vision" instrumentality that unlocks caller ways of perceiving and knowing nan world astir us.

"This breakthrough, which combines expertise from different fields done a collaborative, cross-disciplinary approach, enables nan recognition of invaded crab areas and nan visualization of heavy tissues specified arsenic humor vessels, nerves, and ureters during aesculapian procedures, starring to improved surgical navigation. Additionally, it enables measurement utilizing ray antecedently unseen successful business applications, perchance creating caller areas of non-use and non-destructive testing," remarks Prof. Takemura. "By visualizing nan invisible, we purpose to accelerate nan improvement of medicine and amended nan value of life of physicians arsenic good arsenic patients."


Journal reference:

Takamatsu, T., et al. (2024). Development of a visible and complete 1000 nm hyperspectral imaging rigid-scope strategy utilizing supercontinuum ray and an acousto-optic tunable filter. Optics Express.