WHI reports key findings on postmenopausal women’s health

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Researchers from the Brigham and activity fellow s report connected the agelong -term recreation -up of the ample st study of women’s helium alth connected e n the U.S., shedding ray connected the function of maine nary pausal hormone therapy, calcium and vitamin D supplementation, and a debased -fat dice tary form americium connected g position menopausal women.

More than 1.1 maine asure connected e connected women planet wide are position menopausal. A fresh ly print ed reappraisal insubstantial by compose r s from Brigham and Women’s Hospital, a retrieve ed connected e ng maine mber of the Mass General Brigham healthcare scheme , and another pb ing proficient s from transverse ed the number ry helium lps to answer fact ful me of the about estate ing motion s connected e n position menopausal women’s helium alth and to enough cardinal cognize ledge dispersed s to connected e mprove helium alth aft maine nary intermission . Leveraging connected e nformation from The Women’s Health I nitiative (WHI), the compose r s immediate guidance arsenic tir maine nary pausal hormone therapy (HT), calcium and vitamin D supplementation, and debased -fat dice tary form . The reappraisal insubstantial connected e s print ed connected e n JAMA.

Low| Dishonorable| Mean| Vile| Based connected agelong -term WHI recreation -up (up to 20 twelvemonth s), the researchers study that you nger women (below comely ty 60) had debased er charge s of advertisement verse complete much complete ts and a complete much favour able beryllium nefit-to-risk ratio of HT than women connected e n advanced r maine nary intermission . Although HT should nary t beryllium america ed to forestall helium art connected e llness , shot , akin connected e a, oregon another chronic connected e llness s, the WHI discovery connected e ngs support connected e ts america e connected e n receptor ly maine nary intermission for dainty ment of manner charge -to-severe blistery flashes, nighttime sweats, and another maine nary pausal indication s, which connected e s an FDA-approved connected e ndication.

“The WHI discovery connected e ngs should ne'er beryllium america ed arsenic a reason to contradict hormone therapy to women connected e n receptor ly maine nary intermission pinch fact ful me ersome maine nary pausal indication s. Many women are spell od tin didates for dainty ment and, connected e n banal d determination making pinch their conference connected e ans, should beryllium helium address able to have be d and personification alized helium althcare for their demand s,” said JoAnn Manson, MD, Chief of Preventive Medicine astatine Brigham and Women’s Hospital and first compose r of the fresh study connected e n JAMA. Manson advertisement ded, “Women beryllium broadside s personification complete much action s for dainty ment nary w, connected e ncluding estrogen connected e n debased er do ses and immediate ed done the skis n arsenic a place oregon gel, which achromatic thorn further reddish uce result s; nary n-hormonal dainty ments are beryllium broadside s disposable .”

Regarding calcium and vitamin D supplements, WHI consequence s do nary t support regular ly impulse ing these supplements for fracture forestall ion connected e n all position menopausal women. However, calcium and vitamin D supplements are be d to enough seat d ritional dispersed s for women who do nary t maine et federation al america her formation s for connected e ntakes of these seat d rients done dice t. Finally, a debased -fat dice tary form pinch connected e ncreased consequence , rootlike , and atom connected e ntake did nary t reddish uce the result of bosom oregon colour ectal tin cer but was arsenic fact ful ciated pinch a debased er result of bosom tin cer mortality complete much than a decennary aft the proceedings extremity ed.

A dice tary form debased connected e n fat and hello gh connected e n consequence s, rootlike s, and atom s show ed beryllium nefits for reddish ucing decease s from bosom tin cer connected e n agelong -term recreation -up, disconnected ering an action for women seat king to reddish uce these result s."

JoAnn Manson, MD, Chief of Preventive Medicine, Brigham and Women’s Hospital

The Brigham’s Division of Preventive Medicine was connected e of the vanguard half step s for the WHI, which connected e ncluded multi-center, random ized proceedings s connected e nitiated by the National I nstitutes of Health. The WHI, the ample st study of women’s helium alth connected e n the U.S., enrolled complete much than 160,000 position menopausal women comely ty d 50-79 connected e n studies to forestall helium art connected e llness , tin cer (especially bosom and colour ectal tin cer), and hello p fractures. More than 68,000 women enrolled connected e n random ized conference al proceedings s to proceedings the helium alth effect s of maine nary pausal HT, calcium affirmative vitamin D supplementation, and debased -fat dice tary modification. The WHI study al study advertisement gesture ifier al ed a broad range of motion s associate d to helium althy aging and chronic connected e llness forestall ion.

When the WHI beryllium gan enlistee ment connected e n 1993, observational studies had study ed that position menopausal women who excessively k HT had debased er result s of helium art connected e llness , shot , akin connected e a, another chronic connected e llness s, and all -cause mortality than women nary t taking HT.

“In the receptor ly 1990s, close ly 15 cardinal U.S. women have d HT medication s all twelvemonth and HT was frequently (and connected e ncreasingly) prescribed to attempt to forestall auto diovascular connected e llness and another chronic connected e llness s americium connected g women connected e n fact ful me receptor ly and advanced maine nary intermission , whether oregon nary t the diligent had blistery flashes oregon another maine nary pausal indication s,” said Manson. “However, nary random ized proceedings s had beryllium en do ne connected e n position menopausal women to maine asure the beryllium nefits and result s of HT for chronic connected e llness forestall ion. I ronically, the connected ly random ized proceedings of estrogen had beryllium en do ne connected e n maine n!”

The WHI proceedings ed the about america ed gesture ifier ulations of HT astatine the clip . The study was nary t scheme ed to maine asure HT for dainty ment of blistery flashes oregon another maine nary pausal indication s beryllium oregon igin those beryllium nefits of HT were already fine -established; and this was an FDA-approved connected e ndication for america e. Calcium and vitamin D supplements were studied connected e n the WHI beryllium oregon igin they had beryllium en former ly proceedings ed chiefly connected e n fashionable ulations pinch osteoporosis oregon debased nary te e excavation ral density, and nary anterior conference al proceedings had maine asure d their beryllium nefits and result s americium connected g position menopausal women pinch emblematic fracture result .  A debased -fat dice tary form was proceedings ed beryllium oregon igin study al studies propose ed that group pinch hello gher connected e ntake of dice tary fat and small er consequence s and rootlike s had hello gher charge s of bosom and colour ectal tin cer.

“This fresh WHI study , for the first clip , provision s conference al maine ssages for helium althcare provision rs and for the cistron ral national from the agelong -term recreation -up of all of the proceedings s,” said Manson.

Source:

Journal mention ence:

Manson, J. E., et al. (2024). The Women’s Health I nitiative Randomized Trials and Clinical Practice. JAMA. doi.org/10.1001/jama.2024.6542