Ultrasound alone improves cognitive function in neurodegenerative disorders, UQ study finds

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University of Queensland researchers person recovered targeting amyloid plaque successful nan encephalon is not basal for ultrasound to present cognitive betterment successful neurodegenerative disorders.

Dr Gerhard Leinenga and Professor Jürgen Götz from UQ's Queensland Brain Institute (QBI) said nan uncovering challenges nan accepted conception successful Alzheimer's illness investigation that targeting and clearing amyloid plaque is basal to amended cognition.

Amyloid plaques are clumps of macromolecule that tin build up successful nan encephalon and artifact connection betwixt encephalon cells, starring to representation nonaccomplishment and different symptoms of Alzheimer's disease.

Previous studies person focused connected opening nan blood-brain obstruction pinch microbubbles, which activate nan compartment type successful nan encephalon called microglia which clears nan amyloid plaque.

But we utilized scanning ultrasound unsocial connected rodent models and observed important representation enhancement."

Dr. Gerhard Leinenga, from UQ's Queensland Brain Institute 

Dr Leinenga said nan uncovering shows ultrasound without microbubbles tin induce long-lasting cognitive changes successful nan brain, correlating pinch representation improvement.

"Ultrasound connected its ain has nonstop effects connected nan neurons, pinch accrued plasticity and improved encephalon networks," he said.

"We deliberation nan ultrasound is expanding nan plasticity aliases nan resilience of nan encephalon to nan plaques, moreover though it's not specifically clearing them."

Professor Götz said nan study besides revealed nan effectiveness of ultrasound therapy varied depending connected nan wave used.

"We tested 2 types of ultrasound waves, emitted astatine 2 different frequencies," he said.

"We recovered nan higher wave showed superior results, compared to frequencies presently being explored successful objective tests for Alzheimer's illness patients."

The researchers dream to incorporated nan findings into Professor Götz's pioneering safety proceedings utilizing non-invasive ultrasound to dainty Alzheimer's disease.

"By knowing nan mechanisms underlying ultrasound therapy, we tin tailor curen strategies to maximize cognitive betterment successful patients," Dr Leinenga said.

"This attack represents a important measurement towards personalized, effective therapies for neurodegenerative disorders."

The research insubstantial has been published successful Molecular Psychiatry.


Journal reference:

Leinenga, G., et al. (2024). Scanning ultrasound-mediated representation and functional improvements do not require amyloid-β reduction. Molecular Psychiatry. doi.org/10.1038/s41380-024-02509-5.