Study investigates the potential effects of neonatal vitamin D on eczema up to adulthood

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In a caller study published successful nan diary Nutrients, researchers successful Australia investigated nan imaginable narration betwixt neonatal vitamin D levels and longitudinal eczema improvement up to property 25. They recovered that higher neonatal vitamin D levels correlated pinch reduced likelihood of early-onset persistent eczema and accrued consequence of early-onset-resolving eczema.

 marishkaSm / ShutterstockStudy: Neonatal Vitamin D and Associations pinch Longitudinal Changes of Eczema up to 25 Years of Age. Image Credit: marishkaSm / Shutterstock


Atopic dermatitis, aliases eczema, is simply a communal inflammatory tegument ailment that whitethorn consequence from immunologic disturbance and dysfunction successful nan tegument barrier, while its underlying pathophysiology remains unclear. Evidence suggests that vitamin D levels successful early life whitethorn play a domiciled successful nan improvement of eczema. Vitamin D deficiency and eczema prevalence are higher successful regions pinch little sunlight. Vitamin D receptors successful immune cells propose its engagement successful modulating immune responses. Evidence from cohort studies suggests a nexus betwixt higher cord humor vitamin D levels and reduced consequence of eczema successful early childhood. However, objective tests connected women pinch vitamin D supplementation during gestation person yielded inconsistent results. Current guidelines do not universally urge specified supplementation owed to constricted grounds connected its effects connected allergic diseases successful offspring.

Despite recognizing different eczema phenotypes, nary studies person explored nan relation betwixt longitudinal eczema improvement aliases phenotypes and neonatal vitamin D aliases 25(OH)D3, its astir unchangeable circulating form. Therefore, researchers successful nan coming study aimed to research really neonatal serum 25(OH)D3 levels subordinate to eczema prevalence astatine various ages betwixt 1 and 25 and eczema phenotype up to property 25 years.

About nan study

The Melbourne Atopy Cohort Study (MACS) followed 223 infants pinch a family history of allergic diseases, including self-reported asthma, allergic rhinitis, eczema, aliases terrible nutrient allergy, from commencement to 25 years of age. The infants had Australian-born parents and precocious socioeconomic statuses. Data postulation included telephone surveys, objective examinations, and tegument prick testing (SPT) astatine 6 months and 1, 2, 12, 18, and 25 years. At property 18, participants consented to entree their newborn screening cards for measuring neonatal 25(OH)D3 levels via dried humor spots (DBS).

Prevalent eczema was defined based connected parental aliases self-reports of eczema test aliases rash treated pinch topical steroids. Longitudinal eczema phenotypes were identified utilizing latent people analysis, resulting successful nan pursuing subclasses: early-onset-resolving eczema, early-onset persistent eczema, mid-onset-resolving eczema, mid-onset persistent eczema, and minimal/no eczema. Eczema/sensitization phenotypes were wished based connected eczema and allergen (cow's milk, ovum white, peanut, location particulate mite, feline dander, and ryegrass) sensitization, pinch participants categorized into atopic eczema, non-atopic eczema, asymptomatic-sensitized, aliases asymptomatic groups astatine each age.

Statistical study progressive utilizing logistic regression models, likelihood ratios, generalized estimation equations (GEEs), likelihood ratio tests, Wald tests, directed acyclic graphs, and sensitivity analysis.

Results and discussion

The highest prevalence of eczema was recovered to beryllium successful infancy (31.2%), declining to 15.9% astatine property 6 years and rising to 26% astatine property 25. The median sera-adjusted level of 25(OH)D3 for nan DBS samples was recovered to beryllium 32.5 nmol/L. Consistent pinch expectations, a important relation was observed betwixt vitamin D levels and nan commencement play (p < 0.001), indicating that children calved successful wintertime had little 25(OH)D3 levels. In nan sensitivity analysis, adjusting for commencement season, higher neonatal vitamin D levels were associated pinch reduced eczema consequence astatine 1–2 years. Maternal smoking during gestation was recovered to modify nan association. Further, higher neonatal vitamin D level was recovered to beryllium associated pinch a reduced eczema consequence astatine property 2 years successful participants pinch maternal smoking history, arsenic compared to those without it.

The neonatal vitamin D (25(OH)D3) level successful 223 MACS participants. The median level was 32.5 nmol/L. P25 was 21.6 nmol/L, P75 was 44.7 nmol/L, and mean was 35.9 ± 18.6 nmol/L.The neonatal vitamin D (25(OH)D3) level successful 223 MACS participants. The median level was 32.5 nmol/L. P25 was 21.6 nmol/L, P75 was 44.7 nmol/L, and mean was 35.9 ± 18.6 nmol/L.

Higher neonatal vitamin D levels were recovered to beryllium linked to a alteration successful nan consequence of early-onset persistent eczema (aMOR = 0.74), arsenic good arsenic an summation successful nan consequence of early-onset-resolving eczema (aMOR = 1.30) compared to minimal/no eczema subclass up to property 12 years. Similar trends persisted for eczema phenotypes for up to 25 years. Mother's birthplace influenced nan association— elevated neonatal vitamin D levels were linked to reduced likelihood of early-onset persistent eczema up to 12 years successful children pinch non-Australian/New Zealand-born mothers but not for those pinch Australian/New Zealand-born mothers. Paternal acquisition and maternal prenatal smoking were besides recovered to modify nan relation pinch eczema phenotypes up to 25 years.

The study is strengthened by its power for various confounding factors and prospective design. However, nan study is constricted by its mini sample size, attrition complete time, imaginable for reduced precision successful estimates, and debased generalizability beyond high-allergy-risk cohorts.


In conclusion, nan study indicates that elevated neonatal vitamin D levels could perchance little nan likelihood of early-onset persistent eczema, taxable to imaginable modifications by maternal smoking during gestation and birthplace. Further observational studies successful divers populations are basal to validate these findings. Additionally, well-designed objective tests are warranted to research nan effectiveness of maternal vitamin D supplementation successful preventing eczema, peculiarly early-onset persistent cases.

Journal reference:

  • Neonatal Vitamin D and Associations pinch Longitudinal Changes of Eczema up to 25 Years of Age. Zeng R. et al., Nutrients, 16(9):1303 (2024), DOI: 10.3390/nu16091303,