Specific class of drugs can reverse diet-induced obesity, fatty liver and diabetes in mice

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Researchers astatine Karolinska Institutet whitethorn person recovered a caller measurement to dainty obesity and related disorders by targeting nan cells' powerhouses, nan mitochondria. A study published successful Nature Metabolism shows that a circumstantial people of narcotics that artifact mitochondrial usability tin reverse diet-induced obesity, fatty liver and glucosuria successful mice.

Mitochondria are basal for quality health, arsenic they process nan nutrients successful nan nutrient we eat and harvest nan power needed for various processes successful nan cell. They are cardinal regulators of metabolism, which is very move and tin beryllium rerouted and reprogrammed according to different needs aliases successful consequence to disease.

Increased fat metabolism

Professor Nils-Göran Larsson's investigation group astatine Karolinska Institutet successful Sweden has precocious developed highly circumstantial supplier candidates that artifact mitochondrial function, and frankincense cellular power production, to dainty cancer. Now nan researchers person shown that these narcotics besides person a beneficial effect connected metabolism successful mice.

Four weeks of curen led to an unexpected summation successful fat metabolism, resulting successful a drastic weight loss, a simplification successful fat accumulation successful nan liver and restored glucose tolerance."

Taolin Yuan, postdoctoral researcher at nan Department of Medical Biochemistry and Biophysics, Karolinska Institutet

The curen was fixed orally to antheral obese mice who had been fed a high-fat diet. The astonishing effect suggests that blocking nan cells' power accumulation tin reverse obesity and diabetes.

Collaboration pinch a biotech company

"It's breathtaking that we person identified a caller imaginable strategy for treating communal diseases for illustration obesity and type 2 diabetes," says Professor Nils-Göran Larsson. "We now purpose to further analyse nan mechanisms that tin explicate nan drugs' effect. We person besides initiated a collaboration pinch a biotech institution to spot if this tin beryllium further developed into a curen for humans. Still, it will beryllium galore years earlier we cognize if it works," he concludes.

The study was financed by nan Novo Nordisk Foundation, nan Swedish Diabetes Foundation, nan Swedish Research Council, nan Knut and Alice Wallenberg Foundation, ALF funding, nan Swedish Cancer Society and nan Swedish Brain Foundation. Nils-Göran Larsson is simply a technological laminitis and holds banal successful Pretzel Therapeutics Inc. Three of nan coauthors are labor of Lead Discovery Center and are listed arsenic co-inventors connected a patent exertion concerning mitochondrial RNA polymerase inhibitors for nan curen of cancer.


Journal reference:

Jiang, S., et al. (2024). Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nature Metabolism. doi.org/10.1038/s42255-024-01038-3.

Posted in: Medical Science News | Medical Research News | Biochemistry | Medical Condition News

Tags: Biochemistry, Brain, Cancer, Cell, Diabetes, Diet, Drugs, Fatty Liver, Food, Glucose, Liver, Metabolism, Mitochondria, Nutrients, Obesity, Polymerase, Research, RNA, Therapeutics, Type 2 Diabetes, Weight Loss