Sit less, live healthier: Trial shows blood pressure drops with less sitting

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In a caller study published successful JAMA Network Open, researchers investigated whether reducing sitting clip could efficaciously amended humor unit (BP) among older adults.

 insta_photos/​​​​​​​Study: Sitting Time Reduction and Blood Pressure successful Older Adults. Image Credit: insta_photos/


Sedentary behaviour is associated pinch adverse wellness outcomes specified arsenic cardiovascular disease, type 2 diabetes, debased beingness function, and death. Moderate to mean activity tin use older adults' cognitive, physical, functional, and affectional health; however, their compliance pinch beingness activity is poor, pinch astir of them sitting for overmuch of nan day.

Identifying modifiable variables is captious to improving cardiometabolic fittingness successful older individuals. Short-term experimental investigations show that lowering sitting long reduces humor pressure, peculiarly successful hypertensive individuals.

About nan study

In nan coming randomized controlled trial, researchers evaluated nan effect of sitting clip simplification connected BP readings successful nan geriatric population.

The squad conducted nan Healthy Aging Resources to Thrive (HART) proceedings chiefly remotely astatine nan authorities level during nan terrible acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic betwixt January 2019 and November 2022.

Participants included big Kaiser Permanente Washington (KPWA) attraction recipients, enrolled for astatine slightest a year, aged betwixt 60 and 89 years, sitting for ≥6.0 hours daily, and a assemblage wide scale (BMI) ranging betwixt 30 and 50 kg/m2.

The researchers excluded palliative, long-term, aliases hospice attraction recipients, those pinch cancer, deafness aliases sizeable proceeding impairment, degenerative disorders specified arsenic dementia, aliases adverse intelligence wellness conditions successful nan erstwhile 2 years, diagnosed utilizing nan International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) codes.

The squad randomized nan participants successful a 1:1 ratio to nan sedentary behaviour simplification involution (I-STAND) aliases patient surviving power conditions for six months.

The involution group received 10 wellness enhancement contacts, sedentary clip simplification targets, and a fittingness tracker. The controls received 10 wellness training contacts to found wide patient surviving objectives that excluded beingness activity and sedentary behavior.

The superior study result was sitting long recorded astatine study initiation, 3 months, and six months, utilizing accelerometers for a week astatine each clip point. The researchers monitored systolic BP (SBP) and diastolic BP (DBP) astatine study initiation and aft six months.

The exploratory outcomes included changes successful accelerometer opinionated and stepping time, regular measurement count, number of sitting bouts of ≥30 minutes, mean sitting bouts' duration, clip to execute 5 chair stands from nan Short Physical Performance Battery, and changes successful hypertension medicine classes.

The researchers performed linear regression modeling for analysis, pinch study covariates specified arsenic age, sex, race, ethnicity, residence county, beingness function, status status, diabetes, and hypertension.

They besides performed a sensitivity analysis, separately analyzing information obtained earlier and during coronavirus illness 2019 (COVID-19).


The researchers randomized 283 individuals to nan I-STAND involution (n=140) and power (n=143) groups. The mean subordinate property was 69 years, 186 (66%) were female, and nan mean BMI was 35 kg/m2.

At study initiation, 52% (n=147) suffered from hypertension, and 69% (n=97) consumed 1 aliases much antihypertensive medications. Accelerometer awake clip was astir 16 hours regular complete a week of deterioration successful nan study groups.

The squad noted sedentary clip simplification successful favour of nan I-STAND intervention, pinch an mean quality of 31 minutes per time astatine 3 months and 32 minutes per time astatine six months.

The involution group had a considerably higher mean driblet successful SBP (3.5 mm Hg) aft six months. However, DBP changes were not importantly different crossed nan study groups (0.3 mm Hg).

The sensitivity study showed akin results. The study recovered six awesome adverse events successful some nan I-STAND involution group (two crab diagnoses, 1 emergency section admission, 2 hospitalizations, and 1 fall) and nan power group.

However, location were nary adverse events associated pinch nan trial. They recovered nary important intergroup variations successful BMI, waist circumference, aliases assemblage weight.

The study recovered that opinionated clip roseate while sitting bouts' long and extended sitting bouts were reduced aft six months, favoring nan involution group. Changes successful antihypertensive supplier classes successful some groups were not significant.

Women had importantly little diastolic humor unit than men, but nan effect was minor. Participants successful suburban and agrarian locations demonstrated insignificant improvements successful diastolic humor pressure, supporting nan investigation intervention.


The study findings revealed that lowering sitting clip whitethorn beryllium successfully provided remotely, resulting successful sizeable humor unit decreases. The intervention, which progressive 283 older individuals, decreased sitting long by >30 minutes per time and SBP by astir 3.5 mm Hg.

The findings bespeak that sitting clip simplification by opinionated much and taking much predominant breaks whitethorn beryllium a unsocial manner action for decreasing humor unit that is simpler for older individuals pinch chronic diseases to instrumentality into their mundane lives.

Possible physiological causes for SBP decreases see predominant interruptions to nan bent arterial posture, which whitethorn heighten humor travel and vascular shear stress.

Journal reference:

  • Rosenberg DE, Zhu W, Greenwood-Hickman MA, et al. (2024) Sitting Time Reduction and Blood Pressure successful Older Adults: A Randomized Clinical Trial. JAMA Netw Open. doi: 10.1001/jamanetworkopen.2024.3234.