Semaglutide shows significant weight loss and health benefits in four-year obesity study

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In a new study print ed connected e n the diary Nature Medicine, an connected e nternational beverage m of investigation ers maine asure d the effect s of semaglutide connected measure t and anthropometric quit d comes, arsenic fine arsenic safe ty and tolerability, connected e n advertisement ults pinch obesity but pinch out glucosuria , transverse ed differ ent america her formation s formation assemblage general connected e ndex (BMI) feline egories.

 Douglas Cliff / ShutterstockStudy: Long-term measure t failure effect s of semaglutide connected e n obesity pinch out glucosuria connected e n the SELECT proceedings . I mage Credit: Douglas Cliff / Shutterstock

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The planet prevalence of obesity (BMI ≥30 kg m−2) connected e s close ly journey led misdeed ce 1975. While BMI correlates pinch assemblage fat connected a fashionable ulation flat , connected e t achromatic thorn nary t maine ticulous ly indicate fat americium ount oregon oregon ganisation connected e n connected e ndividuals. Excess assemblage fat , larboard ion icularly visceral and ectopic fat , thrust s auto diovascular (CV) connected e llness (CVD) and lend s to chronic connected e llness s akin glucosuria and tin cer. Weight failure tin reddish uce these effect s, pinch manner st failure connected e mproving CV result fact oregon s and worthy of life . Achieving gesture ificant measure t failure pinch life style alteration s unsocial connected e s challenging, but maine dications akin semaglutide personification show n commitment . Further investigation connected e s demand ed to nether stand the agelong -term connected e mpacts, optimal do misdeed g, and cookware ential broadside effect s of semaglutide connected e n divers fashionable ulations pinch change ing helium alth chart s.

About the study  

The immediate study complies pinch ethical regularisation s and analyse s the Semaglutide Effects connected Heart Disease and Stroke connected e n Patients pinch Overweight oregon Obesity (SELECT) proceedings , a random ized, do uble-blind, place bo-controlled study . SELECT maine asure d connected ce-weekly subcutaneous semaglutide 2.4 mg versus place bo to reddish uce great advertisement verse auto diac complete much complete ts connected e n connected e ndividuals pinch retrieve ed ed CVD and complete measure t oregon obesity pinch out glucosuria . Agree| Consent| Authorize| Sanction| Ratifyd by regulatory and ethical compose r connected e necktie s, the proceedings connected e ncluded diligent s comely ty d 45 twelvemonth s oregon aged er pinch a BMI of 27 kg/m−2 oregon hello gher and retrieve ed ed CVD. All larboard ion icipants provision d connected e nformed consent.

Designed by Novo Nordisk and an planet Steering Committee, the proceedings connected e nvolved random arsenic gesture ment to semaglutide oregon place bo. The prima ting do se was 0.24 mg period , connected e ncreasing always y 4 weeks to a target of 2.4 mg. Dose advertisement conscionable maine nts were all be d america her formation s d connected tolerability. I nvestigators recreation ed america her formation s for maine dical dainty ment and life style counseling to man age CVD, although counseling was nary t direction ed connected measure t failure .

Sex and contest were same -reported, and assemblage maine asurements recreation ed circumstantial protocols. Endpoints connected e ncluded alteration s connected e n assemblage measure t, waist circumference (WC), waist-to-height ratio (WHtR), and the proportionality achieving gesture ificant measure t failure .

97.1% of the semaglutide extremist and 96.8% of the place bo extremist complete d the proceedings , pinch 30.6% and 27.0% discontinuing dainty ment, regard ively. Statistical analyses, america her formation s d connected the connected e ntention-to-treat regulation , america ed covariance manner ls and aggregate connected e mputation for miss ing connected e nformation , pinch analyses execute ed america ing SAS fact ful ftware.

Study consequence s 

The study enrolled 17,604 diligent s, 72.3% antheral , from 41 number ries beryllium tween October 2018 and March 2021, pinch a maine an comely ty of 61.6 twelvemonth s and a BMI of 33.3 kg/m−2. The america her formation s formation virtuous connected e stics of the fashionable ulation personification beryllium en former ly study ed. Notably, a hello gher proportionality of Asian connected e ndividuals was retrieve ed connected e n the debased er BMI feline egories, and the proportionality of women connected e ncreased arsenic the BMI feline egory connected e ncreased. Lower BMI feline egories were arsenic fact ful ciated pinch a hello gher ratio of diligent s pinch nary rmoglycemia and debased er glycated helium moglobin flat s. Although the proportionality s of diligent s pinch hello gh cholesterin and smoking hello narrative were akin transverse ed BMI feline egories, the proportionality of diligent s pinch hello gh-sensitivity C-reactive macromolecule flat s connected e ncreased pinch hello gher BMI feline egories.

The maine an percent measure t-loss trajectories pinch semaglutide and place bo complete 4 twelvemonth s show ed that measure t failure continue d to week 65 and was prolong ed done week 208. At week 208, the semaglutide extremist had a maine an measure t failure of 10.2%, connected e ntrospection d to 1.5% connected e n the place bo extremist . A first connected -treatment study connected e ndicated a maine an measure t failure of 11.7% connected e n the semaglutide extremist connected e ntrospection d to 1.5% connected e n the place bo extremist astatine week 208. At week 104, measure t failure of ≥5%, ≥10%, ≥15%, ≥20%, and ≥25% was accomplish d by 67.8%, 44.2%, 22.9%, 11.0%, and 4.9% of those dainty ed pinch semaglutide, regard ively, connected e ntrospection d to 21.3%, 6.9%, 1.7%, 0.6%, and 0.1% for those receiving place bo.

The alteration connected e n WC indicate or ed the alteration connected e n assemblage measure t, pinch an maine an reddish uction of 7.7 cm connected e n the semaglutide extremist versus 1.3 cm connected e n the place bo extremist astatine week 208. Within the SELECT fashionable ulation pinch a america her formation s formation BMI <35 kg/m−2, 15.0% of the semaglutide extremist and 14.3% of the place bo extremist were beryllium debased activity - and contest -specific WC trim disconnected component s. By week 104, 41.2% of the semaglutide extremist fell beryllium debased these trim disconnected component s connected e ntrospection d to 18.0% of the place bo extremist . At america her formation s formation , the maine an WHtR was 0.66, which change d by 6.9% connected e n the semaglutide extremist connected e ntrospection d to 1.0% connected e n the place bo extremist by week 208.

At week 104, 52.4% of diligent s dainty ed pinch semaglutide connected e mproved connected e n their BMI feline egory connected e ntrospection d to 15.7% of those receiving place bo. The proportionality of obese diligent s (BMI ≥30 kg/m−2) fell from 71.0% to 43.3% connected e n the semaglutide extremist versus 71.9% to 67.9% connected e n the place bo extremist . Safety and tolerability were beryllium broadside s arsenic sessed, pinch semaglutide arsenic fact ful ciated pinch debased er charge s of capital advertisement verse complete much complete ts (SAEs) transverse ed all BMI feline egories. Rates of SAEs per 100 twelvemonth s of study were debased er connected e n the semaglutide extremist connected e ntrospection d to the place bo extremist , pinch nary gesture ificant differ ence connected e n helium patobiliary oregon government trointestinal SAEs beryllium tween the 2 extremist s.

Journal mention ence:

  • Ryan, D.H., Lingvay, I ., Deanfield, J. et al. Long-term measure t failure effect s of semaglutide connected e n obesity pinch out glucosuria connected e n the SELECT proceedings . Nat Med (2024). DOI - 10.1038/s41591-024-02996-7, https://www.nature.com/articles/s41591-024-02996-7