Revolutionizing diabetes management with reliable blood glucose monitoring without finger pricking

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A caller exertion precocious reported successful Nature Metabolism utilizes awesome localization to amended nan accuracy of non-invasive glucose measurement (NIGM).

Study: Non-invasive measurements of humor glucose levels by time-gating mid-infrared optoacoustic signals. Image Credit: Andrey_Popov /

About NIGM

Abbott, Dexcom, and different pharmaceutical companies person released wearable patches that carnivore microneedles designed for intracutaneous implants. These devices connection a much convenient and little achy measurement to show humor glucose levels; however, they tin only measurement glucose levels successful interstitial fluid (ISF) alternatively than wrong nan blood.

ISF glucose leaks from nan humor capillaries, frankincense making ISF levels little than those coming wrong nan blood. Additionally, ISF glucose levels alteration pinch pH, hydration levels, and temperature, nan second of which tin change ISF volume.

Another limitation of NIGM is nan usage of microneedles that could irritate nan tegument and origin microbial infections. This has led researchers to analyse needleless technologies, specified arsenic terahertz (THz) spectroscopy.

THz spectroscopy tin observe glucose based connected ray absorption; however, this method is taxable to comparatively precocious noise, has wide absorption bands, and tin correction glucose for different biomolecules. Raman scattering spectroscopy is different NIGM that uses vibrational spectral profiles to observe glucose. The anemic signals of Raman scattering spectroscopy tin beryllium improved done coherent anti-stokes Raman spectroscopy (CARS) aliases stimulated Raman scattering (SRS).

The existent study discussed nan usage of mid-infrared (mid-IR) absorption spectroscopy, which uses optical, optoacoustic, aliases thermal discovery methods and produces beardown signals. Importantly, 1 situation associated pinch this attack is nan absorption of ray by nan superficial tegument layers alternatively than by glucose, which tin lead to mendacious results.

The researchers aimed to utilize nan beardown signals while improving nan sensitivity and accuracy of glucose discovery utilizing a depth-gated mid-infrared optoacoustic sensor (DIROS). DIROS exploits time-gated mid-IR optoacoustic signals to find nan nonstop extent astatine which glucose absorption is measured successful nan skin.

DIROS detects glucose successful blood-rich tegument areas and, arsenic a result, tin measurement real-time humor glucose levels alternatively than ISF glucose. Importantly, DIROS tin debar glucose sensing from nan stratum corneum and epidermis, frankincense minimizing imaginable errors owed to variations successful tegument humidity aliases nan beingness of fats and different molecules successful nan skin.

Study findings

Mid-IR measurements of humor glucose levels connected a rodent receptor were obtained utilizing depth-selective optoacoustic detection. These measurements were successful statement pinch those obtained by optoacoustic measurements directed astatine nan capillaries astatine 532 nm illumination, frankincense validating nan mid-IR-based findings.

Optoacoustic sensing was utilized to guarantee deeper penetration of nan tegument astatine 100 micrometers (µm) aliases more. The maximum extent was capable to scope nan junction of nan dermis and epidermis, which is rich | successful capillaries, frankincense making real-time humor glucose appraisal possible.

Using astir 5,000 optoacoustic measurement points successful a 70x70 constituent grid, flimsy variety was observed successful nan extent astatine which measurements were collected astatine various points betwixt 4-6%. Accurate humor glucose values pinch capable signal-to-noise ratios (SNR) were besides obtained, thereby allowing in vivo glucose discovery astatine normal concentrations, moreover erstwhile different perchance contaminating molecules for illustration lactate are present.

The measurements were obtained astatine 2 locations, 1 rich | successful humor capillaries (P1) and 1 comparatively avascular (P2). P1 values were person to nan glucometer-recorded humor glucose concentrations arsenic compared to nan P2 values; however, some values changed aft glucose was administered. P2 values changed much slowly, frankincense reflecting nan delayed changes successful ISF glucose.

The astir delicate capacity was achieved for measurements obtained from nan P1 position aft applying a clip gate.”

After demonstrating that vascular areas provided much meticulous and repeatable values, nan investigators explored nan inferior of extent action to heighten DIROS capacity beyond that of presently disposable sensors.

Time-gated measurements eliminated non-specific and bulk measurements from nan tegument aboveground and different tegument molecules utilizing only those from capillary-rich layers of nan skin. Compared to Raman spectroscopy, which detects glucose levels wrong nan 260-460 mg/dL range, DIROS detected changes successful glucose levels beneath 100 mg/dL.

What is nan future?

The existent study presents DIROS, a caller glucose-sensing instrumentality that could thief summation nan precision of humor glucose measurement wrong nan physiological scope successful an effort to beforehand glucosuria management.

DIROS could beryllium extended beyond glucose measurements, aliases instance, nan improvement of a continuous metabolic sensing strategy to alert a personification to deviations from patient metabolic parameter.”

Journal reference:

  • Uluc, N., Glasl, S., Gasparin, F., et al. (2024). Non-invasive measurements of humor glucose levels by time-gating mid-infrared optoacoustic signals. Nature Metabolism. doi:10.1038/s42255-024-01016-9.