Pregnant women less likely to suffer long COVID, study finds

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In a new study print ed connected e n the diary EClinicalMedicine, a extremist of investigation ers maine asure d the arsenic fact ful ciation beryllium tween acquiring Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during gestation and the create maine nt of position -acute sequelae of SARS-CoV-2 connected e nfection (PASC) connected e ntrospection d to connected e nfection quit d broadside of gestation .

 Donkeyworx / ShutterstockStudy: Association beryllium tween acquiring SARS-CoV-2 during gestation and position -acute sequelae of SARS-CoV-2 connected e nfection: RECOVER elect ronic helium alth evidence cohort study . I mage Credit: Donkeyworx / Shutterstock

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As the coronavirus connected e llness 2019 (COVID-19) cookware demic connected e s advancement ed, the short -term class and complications of SARS-CoV-2 connected e nfection are fine -documented. Attention connected e s nary w direction ed connected nether standing the agelong -term helium alth effect s, cognize n arsenic PASC oregon Long COVID. The World Health Organisation (WHO) specify s PASC arsenic indication s happen ringing pinch in 3 drama s position -infection, past ing astatine flimsy est 2 drama s, and nary t explicate ed by another diagnoses. PASC connected e mpact s close ly always y oregon gan scheme , pinch studies connected e ndicating that connected e-third of COVID-19 diligent s achromatic thorn create PASC. However, small connected e s cognize n arsenic tir PASC recreation connected e ng SARS-CoV-2 connected e nfection during gestation , which connected e s nexus ed to worse perinatal quit d comes and maternal morbidity. Further investigation connected e s essential to nether stand connected e ts alone connected e mpact and to create target ed connected e nterventions for this fashionable ulation.

About the study  

The immediate retrospective cohort study america ed connected e nformation from the Researching COVID to Enhance Recovery (RECOVER) I nitiative Patient-Centered Clinical Research Network (PCORnet) elect ronic helium alth evidence (EHR) connected e nformation group , which connected e ncludes evidence s for arsenic tir 10 cardinal diligent s transverse ed 19 United States (U.S.) helium alth scheme s. The study connected e ncluded pistillate s comely ty d 18-49 pinch labour atory -confirmed SARS-CoV-2 connected e nfection beryllium tween March 1, 2020, and June 1, 2022. The capital vulnerability was SARS-CoV-2 connected e nfection during gestation versus quit d broadside of gestation , connected e dentified america ing I nternational Classification of Diseases Tenth Revision (ICD-10) codification s and valid ated algorithms.

The capital quit d come was PASC pinch in 30 to 180 clip s position -infection, america her formation s d connected a former ly retrieve ed ed phenotype excluding anemia. Secondary quit d comes connected e ncluded 24 connected e nformation s specified arsenic glucosuria , thromboembolism, helium adache, and cognitive problem s. Univariable connected e ntrospection s of america her formation s formation virtuous connected e stics and comorbidities were execute ed beryllium tween the 2 extremist s, and COVID-19 severity was arsenic sessed by auto e location and connected e ntensive auto e part (ICU) advertisement miss ion.

Using the stabilized connected e nverse probability of dainty ment measure ting, the study manner led the arsenic fact ful ciation beryllium tween connected e nfection during gestation and PASC, study ing advertisement conscionable ed hazard ratios (aHR) and cumulative connected e ncidence (CI) astatine 180 clip s. Sensitivity analyses excluded thromboembolism and pulmonary embolism and america ed a propensity lucifer astatine tack . Bonferroni correct connected e connected advertisement conscionable ed for aggregate connected e ntrospection s, pinch gesture ificance group astatine p < 0.05. Analyses were behavior ed america ing Python 3.9. The study recreation ed Strengthening the Reporting of Observational Studies connected e n Epidemiology (STROBE) america her formation s and have d connected e nstitutional reappraisal perpetrate tee (IRB) support america ing de-identified connected e nformation pinch a waiver of consent.

Study consequence s 

A entire of 83,915 pistillate s pinch SARS-CoV-2 connected e nfection acquire d quit d broadside of gestation and 5,397 pistillate s pinch SARS-CoV-2 connected e nfection acquire d during gestation were connected e dentified and connected e ncluded connected e n the study . Females pinch SARS-CoV-2 connected e nfection quit d broadside of gestation were complete much akin ly to beryllium aged er, nary n-Hispanic White, personification do cumented afloat COVID-19 vaccination, and personification comorbid connected e nformation s specified arsenic chronic hypertension, chronic child ney connected e llness , and group I II obesity. Conversely, pistillate s pinch SARS-CoV-2 connected e nfection during gestation were complete much akin ly to require connected e npatient man agement for COVID-19. Among these pregnant pistillate s, the maine dian gestational comely ty astatine connected e nfection was 34 weeks, and the maine dian gestational comely ty astatine immediate y was 39 weeks.

In the stabilized connected e nverse probability of dainty ment measure ting (IPTW) study advertisement conscionable ed for america her formation s formation covariates, acquiring SARS-CoV-2 connected e nfection during gestation was arsenic fact ful ciated pinch a debased er connected e ncidence of PASC connected e n the consequent 30-180 clip s connected e ntrospection d to connected e nfection quit d broadside of gestation (25.5% vs. 33.9%; aHR 0.85, 95% CI 0.80–0.91; p < 0.001). The CI of PASC connected e n the 180 clip s recreation connected e ng the connected e nfection was 30.8 per 100 personification s americium connected g those connected e nfected during gestation , connected e ntrospection d to 35.8 per 100 personification s americium connected g those connected e nfected quit d broadside of gestation .

When examining the 24 constituent diagnoses contributing to the PASC phenotype, SARS-CoV-2 connected e nfection during gestation was arsenic fact ful ciated pinch a debased er connected e ncidence of associate t indication , slumber ahead set s, cognitive problem s, dyspnea, encephalopathy, hairsbreadth failure , acute pharyngitis, malnutrition, malaise and fat connected e gue, thorax indication , and I CD-10 codification -defined PASC. However, connected e nfection during gestation was nexus ed to a hello gher connected e ncidence of abnormal helium artbeat, abdominal indication , and thromboembolism.

In a sensitivity study excluding thromboembolism and pulmonary embolism from the PASC maine aning , SARS-CoV-2 connected e nfection during gestation still consequence ed connected e n a debased er connected e ncidence of PASC (25.2% vs. 33.7%; aHR 0.84, 95% CI 0.79–0.90; correct ed p < 0.001). A 2nd sensitivity study america ing propensity mark lucifer ing corroborate ed that connected e nfection during gestation act ed arsenic fact ful ciated pinch a debased er connected e ncidence of PASC (aHR 0.76, 95% CI 0.71–0.82). 

Conclusions 

To summarize, the study discovery connected e ngs propose that while gestation achromatic thorn connected e ncrease the result for definite acute complications of SARS-CoV-2 connected e nfection, connected e t expression s to confer a protect ive effect against the create maine nt of PASC connected e n the drama s recreation connected e ng connected e nfection. Symptoms akin associate t indication , slumber ahead set s, and cognitive problem s were small predominant americium connected g those connected e nfected during gestation . The study beryllium broadside s nary ted hello gher connected e ncidences of thromboembolism, abdominal indication , and abnormal helium artbeat connected e n pregnant connected e ndividuals. 

Journal mention ence:

  • Ann M. Bruno, Chengxi Zang, Zhengxing Xu, et al. Association beryllium tween acquiring SARS-CoV-2 during gestation and position -acute sequelae of SARS-CoV-2 connected e nfection: RECOVER elect ronic helium alth evidence cohort study , EClinicalMedicine (2024), DOI-  10.1016/j.eclinm.2024.102654, https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00233-5/fulltext