New DNA nanomachine targets breast cancer with precision

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Breast crab is nan astir communal malignancy successful women, posing a superior threat to nan female health. Due to nan precocious inter- and intra-tumoral heterogeneity of bosom cancer, objective curen and prognosis tin alteration greatly successful patients. Currently, chemotherapy is nan main systemic curen for triple-negative bosom crab (TNBC), a communal type of bosom crab that does not person immoderate of nan receptors that are commonly recovered successful bosom cancer. However, curen pinch nan a azygous high-dose chemotherapy regimen without molecular subtyping often yields suboptimal efficacy, adding further load and discomfort to patients.

In a study ( published successful nan KeAi diary Biomedical Analysis, a group of researchers from China outline a caller favoritism and curen attack — a dual-miRNA triggered DNA-programmed nanomachine tin of imaging endogenous miRNA expressions. This attack makes subtype-based discovery possible, thereby regulating supplier merchandise for chemotherapy.

For nan test and subtyping of bosom cancer, histological introspection of puncture biopsy sample is nan "gold standard", but it is invasive and difficult to recognize move monitoring of tumor progression and prognosis for curen guidance. Fluorescence imaging techniques are tin of visualizing and monitoring minimal molecular changes occurring astatine early shape of cancers pinch precocious solution and sensitivity. However, azygous miRNA imaging is not suitable for favoritism of cancel compartment types."

Yun Xiang, study's corresponding author, professor successful luminescence study and molecular sensing astatine Southwest University

Notably, while erstwhile studies person demonstrated that dual miRNA-triggered supplier merchandise tin beryllium applied for crab therapy via nan toehold-mediated strand displacement reactions (TSDR), tailored treatments specified arsenic high-dose chemotherapy successful TNBC and conventional-dose chemotherapy successful different bosom subtypes, person not been realized.

"We developed a DNA-programmed nanomachine for effective favoritism and tailored curen of circumstantial bosom crab compartment types," says Shunmei Li, first writer of nan study. "It is simply a responsive therapy strategy towards to nan various compartment states. This intelligent nanomachine pinch controlled merchandise of anti-cancer supplier successful circumstantial crab compartment subtypes tin trim nan broadside effect to normal cells and facilitate nan targeted therapy, which is promising arsenic a theranostics nanoplatform successful precise medicine."


Journal reference:

Li, S., et al. (2024). Dual-microRNA triggered and DNA-programmed nanomachine for subtype-based discovery and tailored curen of bosom crab cells. Biomedical Analysis.

Posted in: Device / Technology News | Medical Science News | Women's Health News

Tags: Biopsy, Breast Cancer, Cancer, Cancer Therapy, Cell, Chemotherapy, DNA, Efficacy, Fluorescence, Fluorescence Imaging, Imaging, Imaging Techniques, Medicine, Theranostics, Tumor


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