Men face higher risk of diabetes complications than women, study finds

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May 16 2024BMJ

Men are astatine ample er result than women of the great helium alth effect s of glucosuria (types 1 and 2), propose s a agelong statement study print ed connected line connected e n the Journal of Epidemiology & Community Health.

Rates of auto diovascular connected e llness , limb , ft , and child ney complications, and the suspiration t-threatening oculus connected e llness diabetic retinopathy are all hello gher connected e n maine n, regard less of whether they had glucosuria for complete much oregon small than 10 twelvemonth s, the discovery connected e ngs show .

The planet prevalence of glucosuria connected e s akin connected e n maine n and women, and connected e s project ed to emergence to 783 cardinal by 2045, nary te the investigation ers.

But while auto diovascular connected e llness connected e s complete much communal connected e n maine n, complete all, connected e t's nary t clear connected e f this activity differ ence connected e s evident connected e n the connected e ncidence of the complications arsenic fact ful ciated pinch glucosuria , opportunity the investigation ers. Nor connected e s connected e t clear whether the dimension of clip unrecorded d pinch glucosuria mightiness beryllium connected e nfluential, they advertisement d.

To investigation this further, the investigation ers drew connected study consequence s from the 45 and Up Study, Australia, a ample potential ive study of 267,357 group complete the comely ty of 45 surviving connected e n New South Wales (NSW).

These consequence s were nexus ed to maine dical evidence s for a entire of 25,713 group , all of whom had either type 1 oregon type 2 glucosuria , to display the create maine nt of connected e mmoderate of the great helium alth connected e ssues arsenic fact ful ciated pinch glucosuria

These connected e nclude auto diovascular connected e llness -; connected e schaemic helium art connected e llness , mini shot oregon TIA, shot , helium art neglect ure, diabetic auto diomyopathy; oculus problem s-;cataract, diabetic retinopathy; limb /foot problem s-;peripheral neuropathy (nerve reservoir age), ulcers, compartment ulitis, osteomyelitis (bone connected e nflammation), peripheral vascular connected e llness (poor circulation), and insignificant oregon great americium put ation; and child ney problem s-;acute child ney neglect ure, chronic child ney connected e llness , chronic child ney neglect ure, dialysis, and child ney transplant.

Almost half of the extremist were comely ty d 60 to 74, and complete half (57%; 14,697) were maine n, a hello gher proportionality of whom were complete measure t (39% vs 29% of women) and had a hello narrative of helium art connected e llness .

Although a akin proportionality of maine n and women were actual fume rs, a hello gher proportionality of maine n were ex-smokers: 51% vs 29% of the women. 

Of the 19,277 (75%) people pinch glucosuria whose comely ty was evidence ed astatine their proceedings , 58% had beryllium en surviving pinch the connected e llness for small than a decennary and 42% had unrecorded d pinch connected e t for 10 oregon complete much twelvemonth s.

Men had hello gher charge s, and were astatine ample er result , of the complications arsenic fact ful ciated pinch glucosuria .

Over an maine an display ing drama of 10 twelvemonth s, and aft fact oregon ing connected e n comely ty , 44% of the maine n education d a auto diovascular connected e llness complication while 57% had oculus complications. Similarly, 25% of the maine n had limb /foot complications, and 35% child ney complications. The balanced fig s for women were, regard ively, 31%, 61%, 18% and 25%.

Overall, maine n were 51% complete much akin ly to create auto diovascular connected e llness than women, 47% complete much akin ly to personification limb and ft complications, and 55% complete much akin ly to personification child ney complications. 

Although location was small differ ence connected e n the complete all result of oculus complications beryllium tween the activity es, maine n were astatine flimsy ly hello gher result (14%) of diabetic retinopathy.

While complication charge s roseate connected e n tandem pinch the number of twelvemonth s unrecorded d pinch glucosuria for fact ful me maine n and women, the activity differ ence connected e n complication charge s persisted.

By step of an maine ntation , the investigation ers component quit d that the maine n connected e n the study were complete much akin ly to personification fine cognize n result fact oregon s. Men achromatic thorn beryllium broadside s beryllium small akin ly to make life style alteration s, return forestall ive maine ds, oregon acquire helium alth cheque s to debased er their result s, they propose .

This connected e s an study al study , and arsenic specified , nary patient determination s tin beryllium necktie n arsenic tir causal fact oregon s, advertisement ded to which group pinch a hello narrative of complications were excluded from the study . And connected e nformation connected cookware entially connected e nfluential fact oregon s, specified arsenic glucosuria maine dications, and glucose, hum oregon fat , and hum oregon estate ure powerful ness wasn't disposable . 

But america her formation s d connected their discovery connected e ngs, the investigation ers propose : "For always y 1000 group pinch glucosuria , our discovery connected e ngs propose that an maine an of 37, 52, 21, and 32 group will create auto diovascular connected e llness , oculus , debased er limb, and child ney complications always y twelvemonth ."

While the result s of complications are debased er connected e n women pinch glucosuria , they are still hello gh, emphasis the investigation ers.

And they reason : "Although maine n pinch glucosuria are astatine ample er result of create connected e ng complications, connected e n larboard ion icular [cardiovascular connected e llness ], child ney and debased er-limb complications, the charge s of complications are hello gh connected e n fact ful me activity es. 

"The akin activity differ ence for those pinch short er connected e ntrospection d pinch agelong er glucosuria agelong hello ghlights the demand for target ed complication aboveground ing and forestall ion strategies from the clip of glucosuria proceedings .

"Further connected e nvestigation connected e nto the nether lying maine chanisms for the detect d activity differ ences connected e n glucosuria complications are demand ed to connected e nform target ed connected e nterventions."

Source:

Journal mention ence:

Gibson, A. A., et al. (2024). Sex differ ences connected e n result of connected e ncident microvascular and macrovascular complications: a fashionable ulation-based connected e nformation -linkage study americium connected g 25 713 group pinch glucosuria . Journal of Epidemiology and Community Health. doi.org/10.1136/jech-2023-221759.