Low vitamin D in children linked to higher atopic dermatitis risk, study finds

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Scientists astatine Chang Gung University, Taoyuan, Taiwan, person conducted a study to research nan relation betwixt vitamin D serum level and allergen sensitization and their effect connected nan consequence of atopic dermatitis successful early childhood.

The study is published successful nan World Allergy Organization Journal.

 alexeisido / ShutterstockStudy: Vitamin D level is inversely related to allergen sensitization for risking atopic dermatitis successful early childhood. Image Credit: alexeisido / Shutterstock

Background

Vitamin D is simply a fat-soluble micronutrient that is important successful modulating innate and adaptive immune responses. Serum levels of this vitamin are associated pinch galore allergic diseases, including atopic dermatitis.

Existing grounds indicates that nan consequence of atopic dermatitis is inversely associated pinch nan serum level of vitamin D. However, insufficient grounds is disposable to understand this relation crossed various property groups during early childhood.

Sensitization to allergens is simply a beardown trigger for atopic dermatitis. While nutrient allergen sensitization typically occurs successful infancy, aeroallergen sensitization occurs much commonly successful childhood. Serum vitamin D levels grounds an inverse relation pinch circumstantial allergen sensitization and full serum immunoglobulin E (IgE) levels successful early childhood.

In this study, scientists person explored nan relation betwixt serum vitamin D levels and puerility atopic dermatitis crossed different property groups. Moreover, they person explored nan effect of vitamin D connected allergen sensitization and atopic dermatitis during early childhood.

Study design

Children pinch clinically confirmed atopic dermatitis and age-matched patient children without atopic dermatitis aliases different allergic diseases were separately enrolled for nan study astatine 0.5, 2, and 4 years of age.

Among children aged 0.5 years, 59 had atopic dermatitis, and 36 were patient controls. Among children aged 2 years, 37 had atopic dermatitis, and 29 were patient controls. Among children aged four, 32 had atopic dermatitis, and 29 were patient controls.

Serum samples collected from nan participants were analyzed for vitamin D, full IgE levels, and allergen-specific IgE levels.

Important observations

The enrolled children were subdivided into 3 groups based connected their serum vitamin D levels. In nan 0.5-year and 4-year property categories, children pinch a vitamin D level of little than 20 ng/ml showed a importantly higher prevalence of exclusive breastfeeding and maternal atopy than those pinch a vitamin D level of much than 30 ng/ml.

Children pinch atopic dermatitis had importantly little vitamin D levels astatine 2 and 4 years of property compared to patient controls. However, a importantly higher vitamin D supplementation was observed successful children pinch atopic dermatitis astatine 0.5 years of property compared to patient controls.

The prevalence of nutrient allergen sensitization was importantly higher successful children pinch atopic dermatitis astatine 0.5 and 4 years of age. The prevalence of mite and IgE sensitization was importantly higher successful children pinch atopic dermatitis astatine 2 and 4 years of age.

Association betwixt vitamin D level and allergen sensitization

Children pinch little than 20 ng/ml of vitamin D showed a higher prevalence of nutrient allergen sensitization astatine 0.5 years of property and mite allergen sensitization astatine 2 years of property compared to those pinch much than 30 ng/ml of vitamin D.

In contrast, a importantly higher prevalence of mite and IgE sensitization was observed only successful children pinch little than 20 ng/ml of vitamin D astatine 4 years of age.

Atopic dermatitis and allergen sensitization consequence factors

Food allergen sensitization and maternal atopy were identified arsenic important consequence factors for nan improvement of atopic dermatitis successful children astatine 0.5 years of age. However, for children astatine 2 and 4 years of age, nan strongest consequence factors for atopic dermatitis were serum vitamin D levels and mite allergen sensitization.

Specifically, serum vitamin D level was identified arsenic a important consequence facet for nutrient allergen sensitization astatine 2 years of property and for mite allergen sensitization astatine some 2 and 4 years of age.

Study significance

The study finds a beardown relation betwixt vitamin D deficiency and atopic dermatitis consequence and a higher prevalence of allergen sensitization during early childhood.

As hypothesized by nan researchers, vitamin D deficiency whitethorn change immune reactions to allergens, which whitethorn lend to atopic dermatitis improvement successful early childhood.

Journal reference:

  • Shen C. 2024. Vitamin D level is inversely related to allergen sensitization for risking atopic dermatitis successful early childhood. World Allergy Organization Journal. https://www.sciencedirect.com/science/article/pii/S1939455124000218