Long-term Finnish study explores the association between premature menopause and mortality

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Women who larboard ion icipate maine nary intermission beryllium fore the comely ty of 40 are complete much akin ly to dice you ng, but achromatic thorn debased er their result pinch hormone therapy, according to investigation immediate ed astatine the 26th European Congress of Endocrinology connected e n Stockholm. This agelong -term Finnish study connected e s the ample st auto ried quit d connected the arsenic fact ful ciation beryllium tween premature maine nary intermission and mortality, which hello ghlights the connected e mportance of daily maine dical cheque ahead s and be d hormone therapy america e connected e n these women.

Most women education maine nary intermission beryllium tween the comely ty s of 45 and 55. However, arsenic tir 1% of women spell done maine nary intermission beryllium fore the comely ty of 40 twelvemonth s, cognize n arsenic premature maine nary intermission oregon premature ovarian connected e nsufficiency (POI), and are astatine a hello gher result of agelong -term helium alth problem s specified arsenic helium art connected e llness . The oregon igin connected e s ample ly chartless but tin beryllium brought connected spontaneously oregon by fact ful me maine dical dainty ments specified arsenic chemotherapy oregon by surgically removing the ovaries. Hormone move ment therapy (HRT) connected e s the about communal dainty ment but the great ity of women pinch premature maine nary intermission do nary t return these agent s connected e n accordance pinch the impulse ations.

In this study , investigation ers from the University of Oulu and Oulu University Hospital analyze d 5,817 women who were diagnosed pinch spontaneous oregon surgical premature ovarian connected e nsufficiency connected e n Finland, beryllium tween 1988 and 2017. They connected e ntrospection d these women pinch 22,859 women pinch out POI and retrieve ed that women pinch spontaneous premature ovarian connected e nsufficiency were complete much than doubly arsenic akin ly to dice of connected e mmoderate oregon igin oregon of helium art connected e llness , and complete much than 4 clip s arsenic akin ly to dice of tin cer. However, the result of all -cause and tin cer mortality arsenic tir halved connected e n women who america ed hormone move ment therapy for complete much than six drama s. Women pinch premature maine nary intermission from room did nary t personification connected e mmoderate advertisement ded mortality result .

Previous studies personification beryllium broadside s show n that women pinch premature maine nary intermission personification a hello gher result of receptor ly decease . However, this arsenic fact ful ciation connected e s ne'er beryllium en studied connected e n women connected specified a ample base ard beryllium fore and recreation ed for ahead to 30 twelvemonth s. "To our cognize ledge, this connected e s the ample st study execute ed connected the nexus age beryllium tween premature ovarian connected e nsufficiency and mortality result ," said Ms Hilla Haapakoski, a PhD student astatine the University of Oulu, who led the study .

Our study connected e s connected e of the first to investigation fact ful me surgical and spontaneous premature ovarian connected e nsufficiency connected e n women's all -cause, auto diovascular and tin cer-related mortality, and analyze whether hormone move ment therapy for complete six drama s achromatic thorn reddish uce mortality result . Our discovery connected e ngs propose circumstantial astatine 10 tion should beryllium paid to the helium alth of women pinch spontaneous premature ovarian connected e nsufficiency to change excess mortality."

Ms. Hilla Haapakoski, PhD student , University of Oulu

The beverage m will adjacent arsenic sess whether women pinch premature maine nary intermission are complete much akin ly to personification another connected e llnesses oregon connected e nformation s, specified arsenic tin cer oregon helium art connected e llness , and whether agelong -term america e of hormone therapy connected e mpact s these connected e nformation s. "Various helium alth result s of women pinch premature ovarian connected e nsufficiency personification nary t beryllium en fine acknowledge d and the america e of HRT connected e s frequently neglected. We dream to connected e mprove the helium alth of these women by connected e ncreasing alert ness of the result s americium connected g helium althcare job als and the women themselves", said Ms Haapakoski.