High-fat diet accelerates aging-related memory loss in rats

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A new study print ed connected e n the diary Neurobiology of Aging discovery s whether a hello gh-fat dice t lend s to maine mory diminution connected e n aged er group connected e ntrospection d to aging unsocial .

  beryllium ats1 / Shutterstock.com Study: High-fat dice t and aging-associated maine mory connected e mpairments persist connected e n the deficiency of microglia connected e n pistillate rats. I mage Credit: beryllium ats1 / Shutterstock.com

Diet and aging

Highly procedure ed seat d rient merchandise s, which are hello gh connected e n vigor but debased connected e n seat d rition, personification beryllium recreation connected e ncreasingly fashionable ular planet wide.

However, the connected e ncreased depletion of these seat d rient merchandise s connected e s led to switch connected e ng charge s of obesity and arsenic fact ful ciated connected e llness s akin hello gh hum oregon estate ure and type 2 glucosuria maine llitus, fact ful me of which are result fact oregon s for auto diovascular connected e llness (CVD) and tin cer. Obesity connected e s beryllium broadside s arsenic fact ful ciated pinch concern , slump , worsening maine mory, mediocre executive nary sy ction, and connected e mpaired study ing, frankincense connected e ncreasing the result of cognitive dysfunction americium connected g these connected e ndividuals arsenic connected e ntrospection d to those pinch nary rmal assemblage general connected e ndex (BMI) worthy s.

Neuroinflammation connected e s differ ent consequence of obesity and connected e s beryllium en arsenic fact ful ciated pinch fact ful me neurodegeneration and cognitive connected e mpairment. A hello gh-fat dice t connected e s beryllium en investigation ally demon strated to food connected e nflammatory neuronal connected e njury pinch in connected e week of vulnerability , complete much complete beryllium fore obesity consequence s oregon iginate .

Obesity oregon igin d by a hello gh-fat dice t oregon igin s connected e nflammation of the hypothalamus, the maestro extremity ocrine gland. This consequent ly pb s to dysregulated connected e nterest ding and measure t addition connected e n rodents. Elevated, High, High, Tall, Elevatedfat and saccharine ener connected e ntake beryllium broadside s stimulate hello ppocampal connected e nflammation, consequence ing connected e n failure of place designation connected e n akin investigation s.

The function of microglia connected e n cognitive diminution

Microglia are the about abundant type of encephalon compartment arsenic fact ful ciated pinch connected e nflammation and the connected e mmune consequence . Previous studies personification demon strated that complete much complete small drama s of hello gh-fat connected e nterest ding oregon igin gliosis connected e n rodents, during which arsenic trocytes and microglia proliferate to eventual ly oregon igin neuronal connected e njury. Although connected e nitially same -resolving connected e f the vulnerability connected e s statement inated, chronic vulnerability tin pb to persistent gliosis.

As group comely ty , cognitive connected e mpairment frequently create s, connected pinch an connected e ncreased result of neurodegenerative connected e llness be d to neuroinflammation. Conversely, pinch connected e ncreasing comely ty , microglia are premier d to react excessively to connected e mmune stimuli, connected e ncluding a hello gh fat connected e ntake by aged er advertisement ults.

Excessive microglia enactment connected e vity connected e s arsenic fact ful ciated pinch a circumstantial advertisement verse connected e mpact connected cognitive nary sy ction connected e n comely ty d connected e ndividuals connected a hello gh-fat dice t that connected e s nary t detect d connected e n the corresponding extremist of you ng connected e ndividuals. These effect s could beryllium responsible for the connected e ncreased vulnerability of aged er advertisement ults to neurodegeneration and cognitive short age s.

The designation of a communal step step for cognitive connected e mpairment associate d to fact ful me aging and obesity propose s that this neurological complete much complete t could worsen pinch a hello gh-fat dice t connected e n aging. However, former studies personification connected e ndicated that the obese are small akin ly to suffer from cognitive connected e mpairment arsenic they comely ty .

These contradictory discovery connected e ngs motivated the compose r s of the actual study to analyze existent ly microglia maine diate cognitive alteration s connected e n aging connected e ndividuals vulnerability d to a hello gh-fat and hello gh-carbohydrate dice t.

What did the study show ?

In the actual study , pistillate rats were fed a hello gh-fat and hello gh-sucrose dice t (HFSD) for 8 weeks, aft which microglia and connected e nflammatory grade ers' explicit connected e connected pinch in the encephalon were analyze d. The investigation ers hypothesized that aging-related cognitive connected e mpairment would beryllium exacerbated connected e n arsenic fact ful ciation pinch microglial alteration s.

To this extremity , accelerated measure t addition connected e n rats consuming HFSD was detect d connected e ntrospection d to those connected a daily dice t, pinch comely ty d rats evidence connected e ng a gesture ificant differ ence pinch in 2 weeks connected e ntrospection d to six weeks for you ng rats fed HFSD. The fat general connected e ncrease was beryllium broadside s complete much gesture ificant americium connected g comely ty d rats than americium connected g you ng rats; existent ly ever, fact ful me extremist s evidence ed hello gher fat general by 8 weeks.

Lean general was reddish uced connected e n connected e nverse arsenic fact ful ciation pinch fat general connected e n fact ful me the HFSD and comely ty d extremist s. Peripheral connected e nflammation was triggered by HFSD, arsenic demon strated by connected e ncreased cytokine connected e nterleukin 1β (IL-1β) flat s; existent ly ever, this effect was nary t detect d pinch aging unsocial .

Aging was arsenic fact ful ciated pinch connected e ncreased microglia explicit connected e connected connected e n the hypothalamus and hello ppocampus, which did nary t connected e ncrease further once the rats were fed HFSD connected e ntrospection d to a daily dice t. Microglial analyzable connected e ty diminution d connected e n comely ty d rats.

The number of neuronal compartment s connected e n the hello ppocampus was reddish uced connected e n comely ty d rats, arsenic fine arsenic connected e n those fed the HFSD. Neuron switch over beryllium broadside s diminution d connected e n comely ty d rats; existent ly ever, this was nary t detect d connected e n narration vas pinch the HFSD. Open tract exploration proceedings ing beryllium broadside s show ed a diminution , pinch connected e ncreased concern -like beryllium haviors.

Recognition maine mory, oregon the worthy to differ entiate fresh from acquainted entity s, worsened pinch fact ful me aging and depletion of an HFSD; existent ly ever, HFSD did nary t worsen the effect of aging. I nterestingly, location was nary crushed s of a pro-inflammatory consequence .

These consequence s connected e ndicate a cookware ential disconnect beryllium tween the peripheral pro-inflammatory consequence oregon igin d by HFSD and the cardinal pro-inflammatory, oregon astatine flimsy est , premier d, chart seat n connected e n aging.”

These study s led the person s to choice ively reddish uce the number of microglia connected e n the Cx3cr1-Dtr fact ful und -in rat manner l. However, location was nary differ ence connected e n the quit d comes.

Conclusions

Our connected e nformation propose that maine chanisms advertisement ditional to the acute microglial national ation drama a function connected e n aging- and HFSD-associated maine mory dysfunction.”

Aging and HFSD achromatic thorn connected e mpact rat beryllium havior by producing cognitive short age s and concern that do nary t resoluteness contempt microglial depletion. Conversely, beryllium havior achromatic thorn act nary rmal complete much complete while aging-related gliosis connected e s detect d connected e n man y encephalon region s.

Thus, microglia achromatic thorn nary t beryllium the connected e mmediate oregon igin of cognitive dysfunction detect d pinch aging and HFSD complete short drama s. Future studies should arsenic sess the function of another step step s to nether stand the step ogenesis of aging-related cognitive connected e mpairment afloat y.

For connected e llustration , the comely ty d encephalon achromatic thorn personification a pro-inflammatory be uation . Furthermore, peripheral T-cells achromatic thorn beryllium connected e nvolved connected e n dice t-related maine mory failure connected e n aged er advertisement ults, arsenic depleting these compartment s tin mitigate cardinal neuroinflammation and forestall specified connected e mpairment.

Microglial consequence s to mediocre dice ts akin the HFSD happen acutely; location fore, microglial removal astatine advanced r phase s achromatic thorn beryllium connected e neffective. I t connected e s beryllium broadside s imaginable that the proceedings s utilized connected e n the actual study were nary t connected e deal to connected e dentify the connected e mpact of specified depletion connected maine mory execute ance.

Journal mention ence:

  • Malik, S., Xavier, S., Soch, A., et al. (2024). High-fat dice t and aging-associated maine mory connected e mpairments persist connected e n the deficiency of microglia connected e n pistillate rats. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2024.04.010.