Heavy drinkers who cut back see major heart health benefits, study finds

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In a caller study published successful JAMA Network Open, a group of researchers explored nan nexus betwixt lowering intoxicant intake and nan occurrence of awesome adverse cardiovascular events (MACEs) successful dense drinkers, focusing connected different subtypes of cardiovascular illness (CVD).

 Vaclav Mach / ShutterstockStudy: Reduced Alcohol Consumption and Major Adverse Cardiovascular Events Among Individuals With Previously High Alcohol Consumption. Image Credit: Vaclav Mach / Shutterstock

Background 

Alcohol depletion importantly influences some individual and nationalist health, pinch investigation showing its analyzable narration pinch CVD. While ray to mean drinking is believed to connection immoderate protection against CVD, this effect varies by nan type of CVD, and nan narration betwixt intoxicant intake and bosom wellness is not linear. Previous studies person typically measured intoxicant depletion astatine a azygous constituent successful clip and compared drinkers to non-drinkers without considering changes successful drinking habits complete time. Further investigation is basal to understand nan mechanisms underlying nan cardiovascular benefits of reduced intoxicant depletion and to found tailored guidelines for different populations and CVD subtypes.

About nan study 

In nan coming study, researchers utilized information from nan Korean National Health Insurance Service–Health Screening (NHIS-HEALS) database to analyse a typical sample of Korean adults aged 40 to 79. Approved by Chungbuk National University Hospital's organization reappraisal committee (IRB) and adhering to nan Declaration of Helsinki and Strengthening nan Reporting of Observational Studies successful Epidemiology (STROBE) guidelines, nan study utilized nan National Health Screening Program's (NHSP's) wide sum to analyse accusation connected demographics, aesculapian histories, and manner factors, including intoxicant consumption. This observant archiving provided a instauration for a elaborate investigation into nan effects of intoxicant connected health.

Participant action was methodical, excluding non-drinkers successful nan second play to debar confounding factors for illustration nan sick-quitter effect. The study's rigor extended to defining dense drinking based connected established criteria and dividing participants into groups based connected their drinking habits complete time. 

Confounding variables were identified pinch precision, including a scope of demographic, health, and manner factors. The study's outcomes centered connected MACEs, pinch elaborate coding and procedures to guarantee accuracy. Statistical analyses were conducted pinch blase devices and methods, including propensity people matching (PSM) and multivariate Cox proportional hazards regression models, to tie reliable conclusions astir nan narration betwixt intoxicant depletion and cardiovascular health.

Study results 

In nan broad study analyzing 21,011 participants pinch initially precocious intoxicant depletion levels, 14,220 maintained their dense drinking habits, while 6,791 reduced their intake to mild aliases mean levels. Predominantly antheral (90.3%) and averaging 56 years of age, this cohort provided a elaborate snapshot of baseline wellness and manner characteristics. Initially, nan dense drinkers were younger connected mean and had a higher proportionality of males compared to those who reduced their intoxicant consumption.

Clinical indicators specified arsenic assemblage wide scale (BMI), humor pressure, and various biochemical markers showed differences betwixt nan groups, pinch nan sustained dense drinkers mostly presenting poorer wellness metrics. Interestingly, contempt nan wellness disparities, aft PSM, these groups were intimately aligned connected astir variables, allowing for a much meticulous comparison of outcomes.

Over nan people of nan study, nan incidence of MACEs was notably higher successful nan group that continued dense drinking compared to those who reduced their intake, pinch a important divergence successful outcomes complete time. Specifically, reduced drinking was associated pinch a 23% little consequence of experiencing a MACE. When examining circumstantial CVDs, reductions successful intoxicant depletion importantly lowered nan consequence of coronary artery illness (CAD), angina, immoderate stroke, ischemic stroke, and all-cause mortality, while nary benefits were observed for nonfatal myocardial infarction (MI) aliases hemorrhagic stroke.

Subgroup analyses highlighted nan cardiovascular advantages of reducing intoxicant intake crossed various demographics and wellness statuses, including age, gender, BMI, smoking status, and levels of beingness activity. Notably, these benefits were evident sloppy of pre-existing conditions for illustration atrial fibrillation and chronic kidney illness and were accordant crossed different socioeconomic statuses and comorbidities.

Further sensitivity analyses, which excluded variables perchance modifiable by intoxicant depletion changes, reaffirmed nan cardiovascular benefits of reducing intoxicant intake. 

Conclusions 

To summarize, successful nan study, dense drinkers who reduced their intoxicant intake demonstrated a importantly little consequence of cardiovascular events complete a decade, pinch notable wellness improvements visible 3 years post-reduction. This simplification successful intoxicant depletion correlated pinch a wide array of cardiovascular benefits, particularly successful lowering nan consequence of ischemic changeable and angina-related interventions. The study clarifies nan analyzable biologic mechanisms done which mean intoxicant depletion whitethorn confer cardiovascular protection, highlighting improvements successful lipid regulation, endothelial function, and reduced inflammation. Importantly, it revealed circumstantial reductions successful CAD and ischemic changeable consequence among dense drinkers, underlining nan imaginable wellness benefits of moderating intoxicant intake.

Journal reference:

  • Kang DO, Lee D, Roh S, et al. Reduced Alcohol Consumption and Major Adverse Cardiovascular Events Among Individuals With Previously High Alcohol Consumption, JAMA Netw Open (2024), DOI: 10.1001/jamanetworkopen.2024.4013, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2816830