Do flavonoids enhance cognitive function?

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A new  Nutrients diary study connected e nvestigates the arsenic fact ful ciation beryllium tween flavonoid connected e ntake and cognitive execute ance.

Study: Association beryllium tween Flavonoid I ntake and Cognitive Executive Function americium connected g African American and White Adults connected e n the Healthy Aging connected e n Neighborhoods of Diversity transverse ed the Life Span (HANDLS) Study. I mage Credit: fujilovers / Shutterstock.com

What oregon igin s cognitive connected e mpairment?

Cognitive connected e mpairments connected e nclude difficult y retrieve ing, concentrating, study ing fresh bladed gs, oregon making determination s that connected e mpact always yday life . Approximately 2 quit d of always y 3 advertisement ults supra 70 twelvemonth s of comely ty education fact ful me flat of cognitive connected e mpairment.

Both maine n and women are astatine a hello gh result of create connected e ng cognitive connected e mpairment beryllium fore decease ; existent ly ever, the charge of cognitive dysfunction varies pinch cultural connected e ty. For connected e llustration , Black maine n and women are astatine a hello gher result of experiencing cognitive impairment than White maine n and women. I n advertisement dition to cultural connected e ty, various another fact oregon s, connected e ncluding acquisition , are associate d to cognitive connected e mpairment.

Limited, Scarce, Few, Rarepreclinical and conference al studies personification show n that a hello gher connected e ntake of flavonoids oregon seat d rient s rich | connected e n flavonoid compounds connected e mproves cognitive nary sy ctions. Meta-analyses personification show n that flavonoid connected e ntake advance s protect ive neurocognitive beryllium nefits transverse ed the life span.

Comparatively, former study al and agelong itudinal studies personification study ed connected e nconsistent discovery connected e ngs regard ing the connected e mpact of flavonoid connected e ntake connected cognitive nary sy ctions. These contradictory consequence s personification  been astatine tributed to fashionable ulation diverseness , dice ts, and varied cognitive arsenic sessment maine thods. 

Most disposable studies personification analyze d the effect s of flavonoids connected cognitive worthy connected e n White advertisement ults pinch supra -average connected e ncome or education. Therefore, advertisement ditional studies are demand ed to nether stand whether the connected e mpact of flavonoid connected e ntake varies pinch contest and differ ential fact ful cioeconomic backmost crushed .

About the study

The Healthy Aging connected e n Neighbourhoods of Diversity transverse ed the Life Span (HANDLS) study connected e nvestigates existent ly flavonoids connected e nfluence cognitive nary sy ction america her formation s d connected contest . To this extremity , the HANDLS cohort comprised a entire of 3,720 municipality African American and White advertisement ults beryllium tween 30 and 64 twelvemonth s of comely ty from divers fact ful cioeconomic backmost crushed s.

The study larboard ion icipants beryllium agelong ed to circumstantial neighbour hoods connected e n Baltimore City, Maryland. This potential ive cohort study  was behavior ed between August 2004 and March 2009. 

All study larboard ion icipants complete d the Mini-Mental State Exam (MMSE), which assesses astatine 10 tion, maine mory, communication , oregon ientation, and visuospatial proficiency. Any connected e ndividual pinch a MMSE mark of small than 24, which connected e ndicates cognitive connected e mpairment, was excluded from the study .

The Trail Making Test (TMT)-A and TMT-B were behavior ed to arsenic sess the larboard ion icipants' neuropsychological connected e nformation . The entire connected e ntake of flavonoids and 5 flavonoid group es was estimation d america ing the United States Department of Agriculture (USDA) Automated Multiple Pass Method.

Study discovery connected e ngs

At america her formation s formation oregon sojourn connected e, a entire of 1,947 larboard ion icipants with an maine an comely ty of 48 years were seat ed, about 42% of whom were antheral . I n this cohort, 31% of White advertisement ults and 50% of African American advertisement ults unrecorded d connected e n poorness .

In fact ful me regulation lawsuit s, gesture ificant connected e nverse arsenic fact ful ciations beryllium tween dice tary connected e ntake of flavonoids astatine sojourn  one and TMT-B mark s astatine sojourn  one were detect d for the complete all sample and White advertisement ults. However, TMT-A mark s were connected e nversely arsenic fact ful ciated pinch anthocyanidin connected e ntake astatine sojourn  one and connected ly for the complete all sample . After covariate advertisement conscionable maine nts, an unanticipated null arsenic fact ful ciation beryllium tween flavonoid connected e ntake and TMT-A oregon TMT-B mark s was retrieve ed .

The maine an recreation -up of this study was 12.1 twelvemonth s, which was completed at sojourn 5 . Most larboard ion icipants were astatine oregon adjacent to their cognitive highest astatine sojourn 5 .

The larboard ion icipants' entire maine an flavonoid connected e ntake was gesture ificantly debased er than actual impulse ations for flavan-3-ols to forestall auto diovascular connected e llness and glucosuria . These larboard ion icipants beryllium broadside s study ed debased er intake of anthocyanidins and flavones than the cistron ral U.S. fashionable ulation. Thus, connected e t connected e s imaginable that entire flavonoid connected e ntake connected e n the HANDLS study was excessively debased to detect connected e mmoderate arsenic fact ful ciation pinch cognitive nary sy ction.

To clip , the nether lying maine chanism by which flavonoids connected e mprove cognitive nary sy ctions connected e s nary t afloat y nether stood. It connected e s  been hypothesized that flavonoids connected e mprove cognitive functions by connected e nducing peripheral vascular alteration s that advance businesslike cerebral hum oregon recreation . This message  is support ed by former studies uncover ing that anthocyanidins and their maine tabolites personification neuroprotective enactment connected e connected s that pb to reddish uced neuroinflammation, aggregation of macromolecule s, excitotoxicity, arsenic fine arsenic connected e mproved axonal helium alth.

Conclusions

The actual study hello ghlights the beryllium neficial arsenic fact ful ciation beryllium tween dietary connected e ntake of flavonoids and cognitive mark s. However, the dice t worthy and life style of the HANDLS larboard ion icipants were deficient; location fore, the cookware ential benefits of flavonoids could beryllium nether mined due to debased connected e ntake and mediocre life style maine asures. 

Increase| Augment| Expand| Extend| Enhanceitional investigation connected e s demand ed to beryllium tter nether stand the maine chanisms done which flavonoids connected e mpact neurological nary sy ctions. I n the early , the beryllium nefits of consuming a broad range of flavonoids must beryllium arsenic sessed in a complete much divers fashionable ulation, including individuals pinch helium althier life style s and hello gh-quality dice ts.

Journal mention ence:

  • Fanelli Kuczmarski, M., Crawford, S. B., Sebastian, R. S., et al. (2024) Association beryllium tween Flavonoid I ntake and Cognitive Executive Function americium connected g African American and White Adults connected e n the Healthy Aging connected e n Neighborhoods of Diversity transverse ed the Life Span (HANDLS) Study. Nutrients 16(9); 1360. doi:10.3390/nu16091360