Can sugar-free biscuits cut appetite in overweight adults? New study explores

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In a caller study published in EBioMedicine, a squad of scientists evaluated nan changes successful endocrine responses and appetite associated pinch acute and repeated exposures to sweeteners and sweetness enhancers specified arsenic Stevia and Neotame and compared it to that of sucrose successful an overweight aliases obese big study population.

 Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits connected postprandial appetite and endocrine consequence successful adults pinch overweight/obesity—a randomised crossover proceedings from nan SWEET consortium. Image Credit: Prasert Wongchindawest/Shutterstock.comStudy: Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits connected postprandial appetite and endocrine consequence successful adults pinch overweight/obesity—a randomised crossover proceedings from nan SWEET consortium. Image Credit: Prasert Wongchindawest/Shutterstock.com

Background

The past fewer decades person seen a accelerated emergence successful unhealthy dietary patterns, pinch obesity and associated metabolic disorders becoming a world nationalist wellness concern. Excessive assemblage weight is often owed to a operation of energy-rich diets and sedentary lifestyles.

In addition, studies person besides recovered that diets mostly comprised of elemental carbohydrates specified arsenic sugars besides consequence successful changes successful hormonal responses that summation weight summation and fat storage.

Given nan debased mineral, vitamin, and fibre contented of sugars and nan problems associated pinch altered endocrine responses and appetite, researchers and policymakers successful wellness and medicine person focused connected reducing aliases eliminating nan intake of free sugars successful diets.

A wide utilized strategy to trim free sweetener intake has been to switch them pinch sweetness enhancers aliases non-nutritive sweeteners.

However, fixed nan absence of grounds connected nan semipermanent benefits of non-nutritive sweeteners, guidelines from nan World Health Organization specify that sweetness enhancers aliases non-nutritive sweeteners should not beryllium considered healthier options if nan fare intends to trim weight aliases little nan consequence of metabolic aliases non-communicable diseases.

These guidelines item nan request for robust studies to understand nan contiguous and semipermanent impacts of non-nutritive sweeteners.

About nan study

In nan coming study, nan researchers conducted a randomized crossover proceedings among a study organization successful England and France consisting of 53 overweight aliases obese adults to understand really nan acute and repeated effect of consuming sweetness enhancers aliases non-nutritive sweeteners differed from that of depletion of free sugars.

Since Stevia and Neotame are 2 of nan wide utilized and approved sweetness enhancers aliases non-nutritive sweeteners successful nan European Union, nan researchers compared nan endocrine responses and appetite changes associated pinch consuming Stevia and Neotame against those of sucrose.

Sucrose was chosen arsenic nan free sweetener successful this investigation since it is wide utilized successful baked equipment not only arsenic a sweetener but besides arsenic a bulking agent, preservative, and moisture source.

The coming study included antheral and female individuals betwixt nan ages of 18 and 60 years who had a assemblage wide scale betwixt 25 and 35 kg per m2, which would categorize them arsenic overweight aliases obese.

In addition, nan eligible participants besides had scores of much than aliases adjacent to 3 connected nutrient wave questionnaires astir habitual depletion of sweets and little than 20 connected a questionnaire astir eating attitudes.

This randomized crossover study progressive nan depletion of fruit-filled biscuits containing Neotame, Stevia, aliases sucrose for 2 weeks, pinch week-long washout periods betwixt each of nan depletion periods. The treatments were besides stratified by property and sex.

Laboratory sessions to measure subjective appetites, specified arsenic desire to eat, hunger, thirst, fullness, nausea, prospective intake, bloating, sensory-specific feelings of satiety, and appetite for saccharine aliases savory foods, were conducted connected nan first and past time of each depletion period.

Additional assessments included nutrient reward, nutrient preferences, and measurements of endocrine and glycemic responses, including insulin, glucose, glucagon-like peptide 1, pancreatic polypeptide, and ghrelin.

Results

The findings showed that nan replacement of sucrose pinch Neotame aliases Stevia importantly reduced postprandial glucose and insulin responses successful adults who were obese aliases overweight while not having immoderate effect connected nan endocrine consequence aliases appetite.

The appetite score, arsenic good arsenic nan results of nan nutrient penchant assessments, showed nary differences associated pinch nan intake of Neotame aliases Stevia.

The alteration successful insulin consequence was akin aft some Neotame and Stevia compared to nan insulin consequence aft sucrose consumption. Still, nan glucose consequence alteration aft Neotame intake was not arsenic important arsenic nan alteration successful glucose consequence aft Stevia intake, compared to nan glucose consequence aft sucrose intake.

The ghrelin, glucagon-like peptide 1, and pancreatic polypeptide levels indicated that nan sweetness enhancers and non-nutritive sweeteners did not effect nan satiety consequence successful nan acute (one day) shape aliases aft repeated exposures.

Conclusions

Overall, nan findings indicated that replacing free sugars specified arsenic sucrose pinch non-nutritive sweeteners specified arsenic Stevia aliases Neotame could alteration nan postprandial glucose and insulin responses but would not effect satiety, appetite, aliases nutrient preferences.

Journal reference:

  • Gibbons, C.,  et al. (2024) Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits connected postprandial appetite and endocrine consequence successful adults pinch overweight/obesity—a randomized crossover proceedings from nan SWEET consortium. EBioMedicine. doi: https://doi.org/10.1016/j.ebiom.2024.105005. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00040-9/fulltext#%20