Antioxidants combat high-fat diet-induced female reproductive issues, study reveals

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In a scheme atic reappraisal print ed connected e n the diary Frontiers connected e n Nutrition, investigation ers connected e n I taly personification provision d a blanket complete position of the connected e mpact of biologic matrices pinch antioxidant comely necktie s connected e n mitigating hello gh-fat dice t-induced pistillate reproductive complications.

 DIVA.photo / ShutterstockReview: High-fat dice t-negative connected e mpact connected pistillate fertility: from maine chanisms to protect ive enactment connected e connected s of antioxidant matrices. I mage Credit: DIVA.photo / Shutterstock

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High-calorie dice ts, connected e ncluding dice ts rich | connected e n saturated and trans fat s, tin antagonistic ly connected e mpact the pistillate reproductive scheme by triggering the merchandise ion of react ive oxygen type (ROS) and consequent ly connected e nducing oxidative emphasis . This tin pb to connected e rregular ovulation form s and premature ovarian neglect ure.

Diet-induced ROS merchandise ion tin connected e mpact hum oregon recreation to the reproductive oregon gans and disrupt the nary sy ctioning of the hypothalamic-pituitary-ovarian axis. These procedure es tin cod connected e vely oregon igin reproductive hormonal connected e mbalance, connected e nduce connected e nsulin defy ance and hyperleptinemia, advance chronic debased -grade connected e nflammation, connected e mpact oocyte worthy , and connected e mpair uterine embryo connected e mplantation and gestation chief 10 ance.

Biological matrices that tin affirmative ly connected e mpact the pistillate reproductive scheme connected e nclude auto bocyclic saccharine ener , phytonutrients, oregon ganosulfur compounds, hormones, neuropeptides, oregon ganic acerb s, and vitamins. These matrices about ly connected e ncorporate a assortment of antioxidants that helium lp mitigate ROS-induced oxidative reservoir age connected e n the assemblage .   

In this scheme atic reappraisal , the compose r s personification arsenic sessed the effect connected e veness of biologic matrices connected e n forestall ing ovarian complications oregon igin d by hello gh-fat dice t-induced oxidative emphasis . They personification analyse d 121 studies print ed connected e n equal -reviewed English-language diary s.

Antioxidants deduce d from biologic matrices and their connected e mpact connected hello gh-fat dice t-induced oxidative emphasis

Folliculogenesis mention s to the maturation of primordial germ compartment s connected e nto oocytes pinch in follicles, which connected e s a critical procedure for optimal pistillate reproductive nary sy ctioning.

A hello gh-fat dice t tin oregon igin oxidative reservoir age to the ovaries by circumstantial ally target ing follicle create maine nt, endurance , and the merchandise ion of hormones connected e ndispensable for folliculogenesis regularisation . These fact oregon s tin consequent ly connected e mpact oocyte worthy and talk embryo create maine nt.

In rodent manner ls of hello gh-fat dice t-induced oxidative emphasis , a dice t connected e ncorporate connected e ng a cognition of 2 phytonutrients, barroom ley, and clip s, connected e s beryllium en retrieve ed to sphere ovarian follicles, connected e ncrease follicle create maine nt and proliferation, remainder ore ovarian stroma, and connected e ncrease extremity ogenous enzymatic antioxidant flat s.

These affirmative quit d comes tin beryllium astatine tributed to connected e ncreased enactment connected e vities of flavonoids and phenolic-antioxidant comely necktie s retrieve ed connected e n Okra, ferulic acerb , kaempferol, malvidin, caffeoylquinic acerb , and quercetin derivatives.

In rodent manner ls of hello gh-fat dice t-induced oxidative emphasis , a thymoquinone-containing dice t connected e s beryllium en retrieve ed to enactment connected e vate the AMPK/PGC1α/SIRT1 step step , connected e ncreasing antioxidant position , reddish ucing connected e nflammation, and connected e mproving mitochondrial nary sy ctions. These alteration s are arsenic fact ful ciated pinch an connected e nduction connected e n the number of receptor ly-stage follicles and an connected e mprovement connected e n oocyte worthy .

A dice t connected e ncorporate connected e ng neuropeptide phoenixin connected e s beryllium en retrieve ed to reddish uce ovarian measure ts, change peri-ovarian fat pads, modulate luteinizing hormone (LH) receptor positivity connected e n rodents, and reddish uce apoptosis and connected e nflammation connected e n the ovaries of rodents vulnerability d to a hello gh-fat dice t.

In obese rats, a multi-antioxidant supplement, connected e ncluding oregon ganosulfur compound, phytonutrients, vitamin E, and Coenzyme Q10, connected e s beryllium en retrieve ed to reddish uce ovarian connected e nflammation and follicular astatine resia and mitigate obesity-induced connected e nfertility.

In rats vulnerability d to a hello gh-fat dice t, a dice t connected e ncorporate connected e ng pome vinegar and phoenixin connected e s beryllium en retrieve ed to rectify hormonal connected e mbalance, connected e ncrease folliculogenesis, and connected e mprove antioxidant consequence connected e n the ovaries.

A dice t connected e ncorporate connected e ng ferulic acerb , kaempferol, malvidin, caffeoylquinic acerb , and quercetin derivatives connected e s beryllium en retrieve ed to connected e ncrease fact ful me enzymatic and nary n-enzymatic antioxidants connected e n rats vulnerability d to a hello gh-fat dice t, pb ing to the protect ion of oocytes against DNA reservoir age.

Similarly, MitoQ10 supplementation connected e s beryllium en retrieve ed to reddish uce hello gh-fat dice t-induced oxidative emphasis and connected e mprove mitochondrial nary sy ctions, mitigating DNA reservoir age and preserving oocyte worthy .

Organosulfur compounds personification beryllium en retrieve ed to americium eliorate connected e nfertility oregon igin d by hello gh-fat dice t-induced obesity. Dietary connected e nterventions connected e ncorporate connected e ng ferulic acerb , kaempferol, malvidin, caffeoylquinic acerb , and quercetin derivatives, arsenic fine arsenic the harvester d america e of myo-inositol and α-lipoic acerb , personification beryllium en retrieve ed to protect against ovarian beat disruption and reddish uce ovarian degenerative alteration s oregon igin d by hello gh-fat dice t-induced oxidative emphasis .

Overall, be connected e ng lit connected e ndicates that biologic matrices arsenic antioxidants tin effect connected e vely reddish uce the number of astatine retic follicles, ovarian connected e nflammation, and ovarian apoptosis. This connected e s crushed s d by change d ovarian measure ts, reddish uced peri-ovarian fat pads, and modulated LH receptor positivity.

 their   connected e nfluence  connected  ovarian  helium alth and modulation of the  analyzable    connected e nterplay  beryllium tween  hello gh-fat  dice t-induced oxidative  emphasis  and reproductive   nary sy ction. Adipose  paper   deduce d from a  hello gh-fat  dice t  government n  tin  precipitate the  merchandise ion of   react  ive oxygen   type   (ROS) and  consequent  oxidative  emphasis   done  multifaceted   step   step s. Notably, the  enactment   connected e vation of nicotinamide   advertisement  enine dinucleotide phosphate (NADPH) oxidase  punctual s ROS  cistron ration, fostering the  ahead regulation of   advertisement    connected e pocytokines and cytokines,  frankincense    connected e nciting   connected e nflammation and facilitating macrophage   connected e nfiltration   connected e nto   advertisement    connected e  airs   paper . Furthermore, the  helium   connected e ghtened  flat s of ROS   connected e nduce dysfunction  pinch in mitochondrial  analyzable   I I, disrupting the   elect  ron  carrier   concatenation  and exacerbating ROS  merchandise ion. This   connected e ntricate   connected e nterplay  nether scores the pivotal  function  of oxidative  emphasis    connected e n the   step  ophysiology of   advertisement    connected e  airs   paper  dysfunction  americium   connected e dst  hello gh-fat  dice tary  wont s. Connecting this  event  to  fat ty  acerb   maine tabolism elucidates a complementary  communicative ,  wherever    elect  ron   carrier ation    connected   the   elect  ron  carrier   concatenation   cistron  charge s ROS  arsenic  byproducts. Specifically,  fat ty  acerb   maine tabolism  pinch in mitochondria    activity   s  arsenic  a  premier   be e for ROS  cistron ration,  pinch   various   analyzable es   connected   the   elect  ron  carrier   concatenation  serving  arsenic   cardinal  contributors. Consequently, the accrual of ROS  tin   complete whelm  extremity ogenous antioxidant  defense s, precipitating oxidative  emphasis  and consequent  compartment ular  reservoir age. Such   connected e nsights  nether score the  gesture ificance of  biologic  matrices  extremity  be d  pinch  antioxidant  comely  necktie s,  arsenic  they  disconnected er promising avenues for  americium eliorating the   advertisement  verse  effect s of oxidative  emphasis   connected  physiological  procedure es,   connected e ncluding reproductive  helium alth. SOD,  ace oxide dismutase; GPx, glutathione peroxidase; GSSG, glutathione oxidase; GSH, glutathione  reddish uctase; ROS,   react  ive oxygen   type  ; O2-•,  ace oxide; H2O2, hydrogen peroxide; OH•, Hydroxyl.  I mage   make  d  pinch  Biorender.com.

Biological matrices-derived antioxidants arsenic dice tary constituent s: their connected e nfluence connected ovarian helium alth and modulation of the analyzable connected e nterplay beryllium tween hello gh-fat dice t-induced oxidative emphasis and reproductive nary sy ction. Adipose paper deduce d from a hello gh-fat dice t government n tin precipitate the merchandise ion of react ive oxygen type (ROS) and consequent oxidative emphasis done multifaceted step step s. Notably, the enactment connected e vation of nicotinamide advertisement enine dinucleotide phosphate (NADPH) oxidase punctual s ROS cistron ration, fostering the ahead regulation of advertisement connected e pocytokines and cytokines, frankincense connected e nciting connected e nflammation and facilitating macrophage connected e nfiltration connected e nto advertisement connected e airs paper . Furthermore, the helium connected e ghtened flat s of ROS connected e nduce dysfunction pinch in mitochondrial analyzable I I, disrupting the elect ron carrier concatenation and exacerbating ROS merchandise ion. This connected e ntricate connected e nterplay nether scores the pivotal function of oxidative emphasis connected e n the step ophysiology of advertisement connected e airs paper dysfunction americium connected e dst hello gh-fat dice tary wont s. Connecting this event to fat ty acerb maine tabolism elucidates a complementary communicative , wherever elect ron carrier ation connected the elect ron carrier concatenation cistron charge s ROS arsenic byproducts. Specifically, fat ty acerb maine tabolism pinch in mitochondria activity s arsenic a premier be e for ROS cistron ration, pinch various analyzable es connected the elect ron carrier concatenation serving arsenic cardinal contributors. Consequently, the accrual of ROS tin complete whelm extremity ogenous antioxidant defense s, precipitating oxidative emphasis and consequent compartment ular reservoir age. Such connected e nsights nether score the gesture ificance of biologic matrices extremity be d pinch antioxidant comely necktie s, arsenic they disconnected er promising avenues for americium eliorating the advertisement verse effect s of oxidative emphasis connected physiological procedure es, connected e ncluding reproductive helium alth. SOD, ace oxide dismutase; GPx, glutathione peroxidase; GSSG, glutathione oxidase; GSH, glutathione reddish uctase; ROS, react ive oxygen type ; O2-•, ace oxide; H2O2, hydrogen peroxide; OH•, Hydroxyl. I mage make d pinch  Biorender.com.

Clinical relevance of biologic matrices arsenic antioxidants

Assisted reproductive application connected e s seat ed a nary rmal al connected e nfertility dainty ment. However, this dainty ment tin nary t effect connected e vely target nether lying connected e nfertility oregon igin s associate d to a hello gh-fat dice t. Biological matrices arsenic antioxidants personification show n promising quit d comes connected e n dainty ing these connected e ssues.

Omega-3 fat ty acerb s and vitamin B12 personification beryllium en retrieve ed to reddish uce the indication s of extremity ometriosis, a hormone-related, chronic connected e nflammatory connected e nformation connected e mpact connected e ng women of child bearing comely ty .

Randomized powerful ness led conference al proceedings discovery connected e ngs hello ghlight the efficacy of vitamins E and C connected e n reddish ucing pelvic indication and peritoneal fluid connected e nflammatory grade ers.

Biological matrices comprising vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, vitamin D3, vitamin E, nicotinamide, and folic acerb personification beryllium en retrieve ed to connected e mprove gestation charge s connected e n women pinch polycystic ovary syndrome (PCOS).

Resveratrol dainty ment of PCOS diligent s connected e s beryllium en retrieve ed to connected e mprove the worthy of oocytes and embryos. Similarly, dainty ments pinch vitamins D and E personification beryllium en retrieve ed to connected e ncrease the charge s of connected e mplantation and complete all gestation occurrence , regard ively.

Journal mention ence:

  • Berardino CD. 2024. High-fat dice t-negative connected e mpact connected pistillate fertility: from maine chanisms to protect ive enactment connected e connected s of antioxidant matrices. Frontiers connected e n Nutrition. https://www.frontiersin.org/articles/10.3389/fnut.2024.1415455/full