A healthier diet is linked with a slower pace of aging, reduced dementia risk, study shows

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A healthier fare is associated pinch a reduced dementia consequence and slower gait of aging, according to a caller study astatine Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center. The findings show that a diet-dementia relation was astatine slightest partially facilitated by multi-system processes of aging. While lit had suggested that group who followed a patient fare knowledgeable a slowdown successful nan processes of biologic aging and were little apt to create dementia, until now nan biologic system of this protection was not good understood. The findings are published successful nan Annals of Neurology.

"Much attraction to nutrition successful dementia investigation focuses connected nan measurement circumstantial nutrients impact nan brain" said Daniel Belsky, PhD, subordinate professor of Epidemiology astatine Columbia School of Public Health and nan Columbia Aging Center, and a elder writer of nan study. "We tested nan presumption that patient fare protects against dementia by slowing down nan body's wide gait of biologic aging."

The researchers utilized information from nan 2nd procreation of nan Framingham Heart Study, nan Offspring Cohort. Originating successful 1971, participants successful nan second were 60 years of property aliases older, were free of dementia, and besides had disposable dietary, epigenetic, and follow-up data. The Offspring Cohort were followed-up astatine 9 examinations, astir each 4 to 7 years. At each follow-up visit, information postulation included a beingness examination, lifestyle-related questionnaires, humor sampling, and, starting successful 1991, neurocognitive testing.

Of 1,644 participants included successful nan analyses, 140 of nan participants developed dementia. To measurement nan gait of aging, nan researchers utilized an epigenetic timepiece called DunedinPACE developed by Belsky and colleagues astatine Duke University and nan University of Otago. The timepiece measures really accelerated a person's assemblage is deteriorating arsenic they turn older, "like a speedometer for nan biologic processes of aging," explained Belsky.

"We person immoderate beardown grounds that a patient fare tin protect against dementia," said Yian Gu, PhD, subordinate professor of Neurological Sciences astatine Columbia University Irving Medical Center and nan different elder writer of nan study, "But nan system of this protection is not good understood." Past investigation linked some fare and dementia consequence to an accelerated gait of biologic aging.

"Testing nan presumption that multi-system biologic aging is simply a system of underlying diet-dementia associations was nan logical adjacent step," explained Belsky. The investigation wished that higher adherence to nan Mediterranean-Dash Intervention for Neurodegenerative Delay fare (MIND) slowed nan gait of aging arsenic measured by DunedinPACE and reduced risks for dementia and mortality. Furthermore, slower DunedinPACE accounted for 27 percent of nan diet-dementia relation and 57 percent of nan diet-mortality association.

"Our findings propose that slower gait of aging mediates portion of nan narration of patient fare pinch reduced dementia risk, and therefore, monitoring gait of aging whitethorn pass dementia prevention," said first writer Aline Thomas, PhD, a Postdoc astatine nan Columbia Department of Neurology and Taub Institute for Research connected Alzheimer's Disease and nan Aging Brain. "However, a information of nan diet-dementia relation remains unexplained, truthful we judge that continued investigation of brain-specific mechanisms successful well-designed mediation studies is warranted."

"We propose that further observational studies beryllium conducted to analyse nonstop associations of nutrients pinch encephalon aging, and if our observations are besides confirmed successful much divers populations, monitoring biologic aging, whitethorn indeed, pass dementia prevention," noted Belsky.

Co-authors are Calen Ryan and Jiayi Zhou, Columbia Aging Center; and Avshalom Caspi, Terrie Moffitt, and Karen Sugden, Duke University.

The study was supported by nan National Institute connected Aging grants R01AG061378, R01AG073402, R01AG059013, R01AG061008, R01AG073207 and R01AG049789.